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Concordance of Quantitative Traits of Diabetes Insipidus and Survival of Litters in Hybrids of Brattleboro and WAG Rat Lines

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Abstract

Mutation di determining diabetes insipidus with a high level of water consumption is fixed in Brattleboro line of rats. We studied effect of mutant di gene replacement into the WAG line of rats under gene c (albino) action. Gene di and albino are inherited as recessive alleles. Alternative dominant alleles di+ and C represent normal copies of genes. Original parent pairs were composed of females of the WAG line with c di+/c di+ genotype and males of the Brattleboro line with C di/C di genotype. The F2 generation split into four phenotypic classes. Investigation of individual water intake and litter sizes of F2 females at the moment of litter weaning revealed a high level of concordance with the coefficient correlation of 0.996.

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Funding

This study was supported by the Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, no. 0259-2021-0014.

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  1. Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    I. I. Khegai

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  1. I. I. Khegai
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Correspondence to I. I. Khegai.

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Conflict of interest. The author declares no conflict of interests.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Novikova

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Khegai, I.I. Concordance of Quantitative Traits of Diabetes Insipidus and Survival of Litters in Hybrids of Brattleboro and WAG Rat Lines. Russ J Genet 57, 1348–1350 (2021). https://doi.org/10.1134/S1022795421110041

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  • DOI: https://doi.org/10.1134/S1022795421110041

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