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Bioinformatic Annotation of Genes for Alzheimer’s Disease and Coronary Heart Disease

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Abstract

In this work, we performed a functional annotation for genes for Alzheimer’s disease (AD) susceptibility and for coronary heart disease (CHD) susceptibility using Cytoscape v. 3.6.0. The identified genes are involved in the immune response and apoptosis and regulate the processes of neurogenesis and angiogenesis. On the basis of the results of the functional annotation, genes for AD predisposition and genes for CHD susceptibility were assigned to terms in accordance with the gene ontology (GO) and combined into groups. The number of common groups of functions in which genes for susceptibility to Alzheimer’s disease and coronary heart disease were involved was 107. Common genes of susceptibility APOE, APOA1, and ABCA1, involved in fatty acid metabolism, can potentially participate in the mechanisms of association of the studied diseases. The results obtained can serve as a prerequisite for further studies of the contribution of hereditary factors to the joint manifestation of AD and CHD.

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  1. Siberian State Medical University, 634050, Tomsk, Russia

    N. Yu. Chasovskikh, E. E. Chizhik & A. A. Bobrysheva

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  1. N. Yu. Chasovskikh
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Chasovskikh, N.Y., Chizhik, E.E. & Bobrysheva, A.A. Bioinformatic Annotation of Genes for Alzheimer’s Disease and Coronary Heart Disease. Russ J Genet 57, 1285–1293 (2021). https://doi.org/10.1134/S102279542111003X

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