Abstract
The mechanism of specific recruitment of the dosage compensation complex (DCC) to the X chromosome of male Drosophila remains an unresolved problem. Recently, a DNA-binding protein CLAMP, which binds to the primary chromosome entry sites (CESs) of the DCC, has been described as a factor involved in X chromosome recruiting of DCC. It has been shown that CESs can recruit DCC to autosomes. In this work, we studied the ability of a well-described CES to support distant interactions in model transgenic Drosophila lines. Negative results were obtained showing that the CES that is bound by CLAMP protein does not support distance interactions.
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This study was supported by the Russian Science Foundation (no. 17-74-20155).
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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Translated by M. Novikova
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Tikhonova, E.A., Mogila, V.A., Georgiev, P.G. et al. The Role of CLAMP Binding Sites in Maintaining of Distant Interactions in Drosophila Transgenic Lines. Russ J Genet 57, 1229–1232 (2021). https://doi.org/10.1134/S1022795421100124
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DOI: https://doi.org/10.1134/S1022795421100124