A replicative analysis of associations with obesity of 53 polymorphic markers associated with the results of genome-wide studies with variability of the body mass index and/or obesity was performed. For the first time in the Russian population, an association with obesity of polymorphic markers rs3810291 of the ZC3H4 gene, rs12940622 of the RPTOR locus, rs1800437 of the GIPR gene, and rs13021737 located in the intergenic region of the genome is shown. Possible molecular mechanisms for the involvement of the studied genes in the pathogenesis of the disease are discussed.
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This study was supported by a grant from the Russian Foundation for Basic Research (project no. 18-04-00758).
Conflict of interest. The authors declare that they have no conflict of interest.
Statement of compliance with standards of research involving humans as subjects. All procedures performed in a study involving people comply with the ethical standards of the institutional and/or national committee for research ethics and the 1964 Helsinki Declaration and its subsequent changes or comparable ethical standards. Informed voluntary consent was obtained from each of the participants.
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Trifonova, E.A., Popovich, A.A., Makeeva, O.A. et al. Replicative Association Analysis of Genetic Markers of Obesity in the Russian Population. Russ J Genet 57, 620–625 (2021). https://doi.org/10.1134/S1022795421050136