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The Role of Genetic Factors in Endocrine Tissues Development and Its Regulation In Vivo and In Vitro

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Abstract

Endocrine cells can be fully functional after heterotopic transplantation into mammals, which makes them a promising tool for regenerative medicine. However, to date, cellular therapy for endocrine diseases is limited by the inability to efficiently and stably obtain endocrine cells in vitro. The review focuses on current knowledge of the molecular genetic mechanisms involved in embryonic development of mouse and human endocrine tissues, as well as the key genetic factors regulating the differentiation of pluripotent stem cells (PSCs) into the endocrine lineage in vitro, using the example of parathyroid cells. The data presented make it possible to suggest an alternative approach to the PSCs differentiation toward parathyroid cells based on genetic engineering by inducing endogenous expression of key differentiation factors.

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This study was supported by the Russian Foundation for Basic Research (grant no. 19-015-00209-A).

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia

    D. V. Goliusova, A. V. Panova & S. L. Kiselev

  2. Endocrinology Research Centre, 117036, Moscow, Russia

    N. V. Klementieva, A. V. Panova & N. G. Mokrysheva

Authors
  1. D. V. Goliusova
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  2. N. V. Klementieva
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  3. A. V. Panova
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  4. N. G. Mokrysheva
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  5. S. L. Kiselev
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Corresponding authors

Correspondence to D. V. Goliusova or S. L. Kiselev.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Statement of compliance with standards of research involving humans as subjects. This article does not contain any research involving humans as a subject.

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Translated by N. Maleeva

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Goliusova, D.V., Klementieva, N.V., Panova, A.V. et al. The Role of Genetic Factors in Endocrine Tissues Development and Its Regulation In Vivo and In Vitro. Russ J Genet 57, 273–281 (2021). https://doi.org/10.1134/S102279542103008X

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  • DOI: https://doi.org/10.1134/S102279542103008X

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