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The Effect of INDEL Polymorphism of the Human Leukocyte Antigen G (HLA-G) and the Season of Birth on the Risk of Schizophrenia and Its Clinical Features

  • HUMAN GENETICS
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Abstract

By modulating the immunological relationship between the mother and the fetus, as well as interacting with various environmental factors, HLA-G plays an important role in the development of the brain of the embryo and is therefore considered as one of the risk factors for schizophrenia. We studied the relationship of INDEL HLA-G gene polymorphism with schizophrenia and its clinical features, taking into account the season of birth. The sample of patients included 1171 people with schizophrenia; the control group consisted of 575 mentally healthy people without a family history of mental disorders. The interaction of INDEL polymorphism and the season of birth was revealed. It has been found that, in men with the D/D genotype born in the summer, the risk of schizophrenia increases (OR = 1.95, 95% CI: 1.01–3.78). Our analysis has shown that the INDEL polymorphism does not interact with the season of birth as an environmental factor and does not affect the clinical features of schizophrenia: the age of onset of the disease and the severity of symptoms.

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Funding

This work was carried out with financial support from the Ministry of Education and Science of the Russian Federation within the framework of the state assignment on scientific topic 0508-2019-0035.

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  1. Mental Health Research Center, 115522, Moscow, Russia

    G. I. Korovaitseva, M. V. Gabaeva, I. V. Oleichik & V. E. Golimbet

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  1. G. I. Korovaitseva
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Correspondence to G. I. Korovaitseva.

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All patients gave informed consent for collection of biological material, collection of anamnesis, testing, and molecular genetic research.

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Korovaitseva, G.I., Gabaeva, M.V., Oleichik, I.V. et al. The Effect of INDEL Polymorphism of the Human Leukocyte Antigen G (HLA-G) and the Season of Birth on the Risk of Schizophrenia and Its Clinical Features. Russ J Genet 57, 221–226 (2021). https://doi.org/10.1134/S102279542102006X

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