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Analysis of the Association of Haplotypes with Alzheimer’s Disease and Mild Cognitive Impairment in the Russian Population

Abstract

Haplotype associations of 894 DNA samples of elderly people from the Russian population of Tomsk were analyzed using 49 SNPs (single nucleotide polymorphisms). As the analyzed markers, SNPs were selected that showed an association with Alzheimer’s disease or variability of cognitive abilities in genome-wide association studies. As a result of the analysis, blocks on chromosomes 1, 2, 6, 8, 11, 19, and 20 were identified. Significant associations were shown, taking into account 50 000 permutations, for haplotypes localized on chromosomes 1 and 19 in the genes CR1 and APOE, APOC1, respectively. Our results confirm the role of the APOE and CR1 genes in the pathogenesis of Alzheimer’s disease in the Russian population.

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Correspondence to K. V. Vagaitseva.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in a study involving people comply with the ethical standards of the institutional and/or national committee for research ethics and the 1964 Helsinki Declaration and its subsequent changes or comparable ethical standards. Each of the participants in the study gave informed consent.

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Vagaitseva, K.V., Bocharova, A.V., Kolesnikova, E.A. et al. Analysis of the Association of Haplotypes with Alzheimer’s Disease and Mild Cognitive Impairment in the Russian Population. Russ J Genet 56, 1272–1276 (2020). https://doi.org/10.1134/S1022795420100130

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  • DOI: https://doi.org/10.1134/S1022795420100130

Keywords:

  • analysis of associations
  • linkage disequilibrium
  • Alzheimer’s disease
  • haplotypes
  • Russian population