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Functional Annotation of Genes of Predisposition to Schizophrenia and Celiac Disease

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Abstract

In the present study, a functional annotation of genes predisposing to schizophrenia and celiac disease was carried out using Cytoscape version 3.7.1. The identified genes are involved (even jointly) in the regulation of the development and functioning of nerve cells and activation of the immune response. Common genes for both diseases (NOTCH4 and HLA-DQA1) are hereditary factors in the development of schizophrenia and celiac disease. According to the results of functional annotation, genes susceptible to schizophrenia and celiac disease were annotated by terms from Gene Ontology; the number of common groups of functions was 44. The results suggest that molecular mechanisms responsible for the differentiation and proliferation of cells of both the immune system and the nervous system are involved in the comorbid development of schizophrenia and celiac disease. It was found that a significant number (up to 179) of genes could be involved in the implementation of a single biological process. However, in some cases, the same gene could be represented in several related processes.

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Authors and Affiliations

  1. Siberian State Medical University, 634050, Tomsk, Russia

    N. Yu. Chasovskikh & A. Yu. Grechishnikova

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  1. N. Yu. Chasovskikh
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Correspondence to A. Yu. Grechishnikova.

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The present study contains no data on research involving animals or humans as the objects of the study.

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Translated by A. Kazantseva

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Chasovskikh, N.Y., Grechishnikova, A.Y. Functional Annotation of Genes of Predisposition to Schizophrenia and Celiac Disease. Russ J Genet 56, 1246–1251 (2020). https://doi.org/10.1134/S1022795420100038

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