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Expression of the Ca2+-ATPase SERCA2a (ATP2A2) Gene and the Ryanodine Receptor (RYR2) Gene in Patients with Chronic Heart Failure

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Abstract

The analysis of the relative expression of the Ca2+-ATPase SERCA2a gene (ATP2A2) and the ryanodine receptor (RYR2) gene in the myocardium of 85 patients with coronary artery disease complicated by heart failure, depending on the clinical picture of the disease, was performed. A decrease in the expression level of the ATP2A2 and RYR2 genes in patients with left ventricular hypertrophy was revealed. It was established that the expression level of the RYR2 gene decreased with the severity of the functional class of heart failure. A correlation was found between the expression level of the ATP2A2 gene and the echocardiography parameters.

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Funding

This work was supported by the Russian Foundation for Basic Research, grant no. 17-04-01450, “Study of the Association of Polymorphisms and Expression of Genes of Ca2+-Transporting Proteins of the Sarcoplasmic Reticulum with Severity of Heart Failure.”

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Authors and Affiliations

  1. Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012, Tomsk, Russia

    E. F. Muslimova, T. Yu. Rebrova, D. S. Kondratieva, Sh. D. Akhmedov & S. A. Afanasiev

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  1. E. F. Muslimova
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  2. T. Yu. Rebrova
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  3. D. S. Kondratieva
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  4. Sh. D. Akhmedov
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  5. S. A. Afanasiev
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Correspondence to E. F. Muslimova.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Muslimova, E.F., Rebrova, T.Y., Kondratieva, D.S. et al. Expression of the Ca2+-ATPase SERCA2a (ATP2A2) Gene and the Ryanodine Receptor (RYR2) Gene in Patients with Chronic Heart Failure. Russ J Genet 56, 843–848 (2020). https://doi.org/10.1134/S1022795420070108

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  • DOI: https://doi.org/10.1134/S1022795420070108

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