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Association of Gene Polymorphisms of Antioxidants with Reproductive Losses

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Abstract

The frequencies of genotypes and alleles for SNP of antioxidant genes (SOD1, SOD2, CAT, GPX4) and EDN1 and NOS3 were investigated in women with pregnancy loss. The 7958A allele of the SOD1 gene was associated with an increased risk of spontaneous abortion in the first trimester (OR = 2.17, 95% CI = 1.14–4.13). Women with the Asn/Asn genotype of the EDN1 gene have an increased risk of miscarriage in the first trimester (OR = 7.18, 95% CI = 1.4–36.75). An association with increased risk of pregnancy loss in the first trimester was found for the NOS3 –786T allele (OR = 1.68, 95% CI = 1.04–2.72). The significant models of gene-gene interaction changing the risk of miscarriage were revealed.

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Funding

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (project no. 6.6762.2017).

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Authors and Affiliations

  1. Southern Federal University, 344090, Rostov-on-Don, Russia

    E. V. Mashkina, K. A. Kovalenko, A. V. Miktadova & M. A. Shkurat

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  1. E. V. Mashkina
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  2. K. A. Kovalenko
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Correspondence to E. V. Mashkina.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Mashkina, E.V., Kovalenko, K.A., Miktadova, A.V. et al. Association of Gene Polymorphisms of Antioxidants with Reproductive Losses. Russ J Genet 56, 354–362 (2020). https://doi.org/10.1134/S1022795420030114

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  • DOI: https://doi.org/10.1134/S1022795420030114

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