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Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension

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Abstract

The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/substrains of rats, the maximum frequency of occurrence of identical SNPs in different strains was 0.58 (i.e., in 7 of 12 hypertensive strains/substrains). The analysis of the genomic sequences of 11 hypertensive strains/substrains of rats, which model different forms of arterial hypertension, also did not reveal a single SNP common to all 11 hypertensive strains/substrains of rats taken in the analysis. Analysis of experimental data suggests that hypertension is a genetically heterogeneous disease.

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Funding

This work was supported by budget projects 0324-2019-0041 and 0324-2019-0042. The studies were carried out using the equipment of the Center for Genetic Resources of Laboratory Animals at the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, supported by the Russian Ministry of Education and Science (unique project identifier RFMEFI62117X0015). Computational analysis of the data was carried out using the resources of the Siberian Supercomputer Center of the Institute of Computational Mathematics and Mathematical Geophysics, Siberian Branch, Russian Academy of Sciences.

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Authors and Affiliations

  1. Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    O. E. Redina, V. A. Devyatkin, N. I. Ershov & A. L. Markel

  2. Department of Molecular Biology and Biotechnology, Novosibirsk State University, 630090, Novosibirsk, Russia

    O. E. Redina, V. A. Devyatkin & A. L. Markel

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  1. O. E. Redina
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  2. V. A. Devyatkin
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  3. N. I. Ershov
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  4. A. L. Markel
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Correspondence to O. E. Redina.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Redina, O.E., Devyatkin, V.A., Ershov, N.I. et al. Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension. Russ J Genet 56, 213–225 (2020). https://doi.org/10.1134/S1022795420020106

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