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Molecular Genetic Study of Association of the MTRR Gene A66G SNP with Dental Caries in Children with Congenital Cleft Lip and/or Palate and without Pathology

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Abstract

Association of the A66G SNP in the MTRR gene with dental caries was studied in children with congenital anomalies of the maxillofacial region (CA of MFR), i.e., with congenital cleft lip with or without cleft palate (CL, CP, and CLP) and in children without congenital anomalies. Comparison of samples of children with CL, CP, and CLP and children without congenital anomalies revealed association of the A66G SNP of the MTRR gene with the considered anomalies, which made it impossible to establish probable association of this marker with caries (for the G/G genotype, an association with the increased risk for developing CA of MFR was observed: OR = 2.16; P = 0.046; 95% CI (1.00–4.67). In children without pathology, an association of the A66G SNP of the MTRR gene with early caries was revealed. In carriers of the A/A genotype among children with primary and mixed bite (N = 91) and the mean age of 6.51 ± 0.2 years, the risk for developing more severe form of caries was higher: OR = 4.91; P = 0.006; 95% CI (1.53–15.78); and among children with primary bite (N = 53) and the mean age of 4.71 ± 0.18 years, OR = 10.53; P = 0.024; 95% CI (1.19–485.29). In children with heterozygous A/G genotype, the resistance to more severe form of caries was observed. Therefore, the A66G SNP of the MTRR gene can be considered as a marker of early caries in children without congenital anomalies.

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Funding

This study was supported by budget financing in terms of the state contract “Genomic Studies and Genetic Polymorphism of a Cell, Organism, and Population” (no. 0112-2019-0001).

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia

    I. G. Udina, V. S. Uchaeva & A. S. Gracheva

  2. Kuban State Medical University, 350063, Krasnodar, Russia

    V. V. Volobuyev & Yu. A. Vasiliev

Authors
  1. I. G. Udina
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  2. V. S. Uchaeva
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  3. V. V. Volobuyev
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  4. A. S. Gracheva
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  5. Yu. A. Vasiliev
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Correspondence to I. G. Udina.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by N. Maleeva

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Udina, I.G., Uchaeva, V.S., Volobuyev, V.V. et al. Molecular Genetic Study of Association of the MTRR Gene A66G SNP with Dental Caries in Children with Congenital Cleft Lip and/or Palate and without Pathology. Russ J Genet 55, 1577–1581 (2019). https://doi.org/10.1134/S1022795419120111

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