Populations of the indigenous ethnic groups of Northern Eurasia are of considerable interest for population genomics, both because they have been relatively poorly studied with the use of modern genomic technologies and owing to the specificity of their gene pools that developed in various genetic-demographic conditions. We used genotype data on 242 179 autosomal SNPs of 876 individuals to search for regions with runs of homozygosity of more than 1 Mb. For Siberian populations, the number of runs of homozygosity and their total length was higher than for other populations of Northern Eurasia.
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This work was carried out within the framework of the Union State Scientific and Technical Program “Development of Innovative Geno-Geographic and Genomic Technologies for Identifying the Personality and Individual Human Characteristics Based on the Study of Gene Pools of the Union State Regions (DNA Identification),” state contract no. 011-17 of September 26, 2017, and also supported by the Russian Foundation for Basic Research grant no. 18-29-13045 “Human Population Genomics and Transcriptomics: Search for the Signals of Non-Neutral Evolution.”
Conflicts of interest. The authors declare that they have no conflict of interest.
Statement on the welfare of animals. All procedures carried out in a study involving people comply with the ethical standards of the institutional and/or national research ethics committee and the 1964 Helsinki Declaration and its subsequent changes or comparable standards of ethics. Informed voluntary consent was obtained from each of the participants in the study.
Translated by K. Lazarev
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Kolesnikov, N.A., Kharkov, V.N., Zarubin, A.A. et al. Characteristics of Genomic Distribution of Runs of Homozygosity in the Indigenous Population of Northern Eurasia. Russ J Genet 55, 1294–1298 (2019). https://doi.org/10.1134/S1022795419100077