Abstract
Populations of the indigenous ethnic groups of Northern Eurasia are of considerable interest for population genomics, both because they have been relatively poorly studied with the use of modern genomic technologies and owing to the specificity of their gene pools that developed in various genetic-demographic conditions. We used genotype data on 242 179 autosomal SNPs of 876 individuals to search for regions with runs of homozygosity of more than 1 Mb. For Siberian populations, the number of runs of homozygosity and their total length was higher than for other populations of Northern Eurasia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Pemberton, T.J., Absher, D., Feldman, M.W., et al., et al. Genomic patterns of homozygosity in worldwide human populations, Am. J. Hum. Genet., 2012, vol. 8, no. 91, pp. 275–292. https://doi.org/10.1016/j.ajhg.2012.06.014
Ropers, H.H., New perspectives for the elucidation of genetic disorders, Am. J. Hum. Genet., 2007, vol. 81, pp. 199–207. https://doi.org/10.1086/520679
Ceballos, F.C., Joshi, P.K., Clark, D.W., et al., Runs of homozygosity: windows into population history and trait architecture, Nat. Rev. Genet., 2018, vol. 19, no. 4, pp. 220–234. https://doi.org/10.1038/nrg.2017.109
Triska, P., Chekanov, N., Stepanov, V., et al., Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe, BMC Genet., 2017, vol. 18, suppl. 1, p. 110. https://doi.org/10.1186/s12863-017-0578-3
Stepanov, V.A. and Puzyrev, V.P., Y-Chromosome microsatellite haplotypes demonstrate absence of subdivision and presence of several components in the Tuvinian male gene pool, Russ. J. Genet., 2000, vol. 36, no. 3, pp. 298–204.
Stepanov, V.A. and Puzyrev, V.P., Analysis of the allele frequencies of seven Y-chromosome microsatellite loci in three Tuvinian populations, Russ. J. Genet., 2000, vol. 36, no. 2, pp. 179–185.
Stepanov, V.A., Khar’kov, V.N., and Puzyrev, V.P., Evolution and phylogeography of human Y-chromosomal lineages, Inf. Vestn. Vavilovskogo O-va Genet. Sel., 2006, vol. 10, no. 1, pp. 57–73.
Khitrinskaya, I.Yu., Stepanov, V.A., and Puzyrev, V.P., Genetic peculiarity of the Yakut population as inferred from autosomal loci, Mol. Biol. (Moscow), 2003, vol. 37, no. 2, pp. 205–209. https://doi.org/10.1023/A:1023389420299
Stepanov, V.A., Etnogenomika naseleniya Severnoi Evrazii (Ethnogenomics of the Northern Eurasia Population), Tomsk: Pechatnaya Manufaktura, 2002.
Purcel, Sh. and Chang, Ch., PLINK [1.9]. http://www.cog-genomics.org/plink/1.9/.
Kharkov, V.N., Khamina, K.V., Medvedeva, O.F., et al., Gene pool of Buryats: clinal variability and territorial subdivision based on data of Y-chromosome markers, Russ. J. Genet., 2014, vol. 50, no. 2, pp. 180–190. https://doi.org/10.1134/S1022795413110082
Kharkov, V.N., Stepanov, V.A., Medvedeva, O.F., et al., The origin of Yakuts: analysis of the Y-chromosome haplotypes, Mol. Biol. (Moscow), 2008, vol. 42, no. 2, pp. 198–237.
Sajantila, A., Salem, A.H., Savolainen, P., et al., Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population, Proc. Natl. Acad. Sci. U.S.A., 1996, vol. 93, no. 21, pp. 12035–12039.
Funding
This work was carried out within the framework of the Union State Scientific and Technical Program “Development of Innovative Geno-Geographic and Genomic Technologies for Identifying the Personality and Individual Human Characteristics Based on the Study of Gene Pools of the Union State Regions (DNA Identification),” state contract no. 011-17 of September 26, 2017, and also supported by the Russian Foundation for Basic Research grant no. 18-29-13045 “Human Population Genomics and Transcriptomics: Search for the Signals of Non-Neutral Evolution.”
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest. The authors declare that they have no conflict of interest.
Statement on the welfare of animals. All procedures carried out in a study involving people comply with the ethical standards of the institutional and/or national research ethics committee and the 1964 Helsinki Declaration and its subsequent changes or comparable standards of ethics. Informed voluntary consent was obtained from each of the participants in the study.
Additional information
Translated by K. Lazarev
Rights and permissions
About this article
Cite this article
Kolesnikov, N.A., Kharkov, V.N., Zarubin, A.A. et al. Characteristics of Genomic Distribution of Runs of Homozygosity in the Indigenous Population of Northern Eurasia. Russ J Genet 55, 1294–1298 (2019). https://doi.org/10.1134/S1022795419100077
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1022795419100077