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Development of Multiplex Genotyping Method of Polymorphic Markers of Genes Associated with Cognitive Abilities

Russian Journal of Genetics volume 54, pages 740–745 (2018)Cite this article

Abstract

A developed method of multiplex genotyping of polymorphic markers of genes associated with cognitive abilities and neuropsychiatric diseases is based on multilocus PCR and MALDI-TOF mass spectrometry of DNA molecules. The frequencies of 32 single-nucleotide markers localized in 24 genes are analyzed in a sample of elderly people from the Russian population of Tomsk. The data obtained are compared with data for populations from the 1000 Genomes Project.

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Author information

Authors and Affiliations

  1. Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, 634050, Russia

    K. V. Vagaitseva, A. V. Bocharova, A. V. Marusin, O. A. Makeeva & V. A. Stepanov

  2. National Research Tomsk State University, Tomsk, 634050, Russia

    K. V. Vagaitseva, E. A. Kolesnikova & V. A. Stepanov

  3. Center for Clinical Trials, Nebbiolo LLC, Tomsk, 634009, Russia

    O. A. Makeeva

Authors
  1. K. V. Vagaitseva
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  2. A. V. Bocharova
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  3. A. V. Marusin
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  4. E. A. Kolesnikova
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  5. O. A. Makeeva
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  6. V. A. Stepanov
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Corresponding author

Correspondence to K. V. Vagaitseva.

Additional information

Original Russian Text © K.V. Vagaitseva, A.V. Bocharova, A.V. Marusin, E.A. Kolesnikova, O.A. Makeeva, V.A. Stepanov, 2018, published in Genetika, 2018, Vol. 54, No. 6, pp. 719–726.

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Vagaitseva, K.V., Bocharova, A.V., Marusin, A.V. et al. Development of Multiplex Genotyping Method of Polymorphic Markers of Genes Associated with Cognitive Abilities. Russ J Genet 54, 740–745 (2018). https://doi.org/10.1134/S1022795418060121

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