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Schizophrenia Genetics

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Abstract

Schizophrenia is a complex multifactorial disease, in most cases manifested as a result of the interaction of genetic and psychological factors, as well as certain environmental conditions. However, genetic factors certainly play a determining role in the predisposition to schizophrenia. The coefficient of heritability of schizophrenia is about 80%, which is typical of the most highly inherited multifactorial diseases. This review presents the results of the latest world studies of genetic factors in the development of schizophrenia, including epigenetic, genome-wide association studies, and next generation sequencing.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Russia

    A. E. Gareeva & E. K. Khusnutdinova

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  1. A. E. Gareeva
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  2. E. K. Khusnutdinova
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Correspondence to A. E. Gareeva.

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Original Russian Text © A.E. Gareeva, E.K. Khusnutdinova, 2018, published in Genetika, 2018, Vol. 54, No. 6, pp. 585–596.

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Gareeva, A.E., Khusnutdinova, E.K. Schizophrenia Genetics. Russ J Genet 54, 593–603 (2018). https://doi.org/10.1134/S1022795418050046

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  • DOI: https://doi.org/10.1134/S1022795418050046

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