Abstract
Chromosomes of embryos of couples with reduced number of morphologically normal sperm cells (less than 4%) and couples with a normal level of morphologically normal sperm cells (over 4%) has revealed significant differences. In the group with a low level of normal spermatozoa, the frequency of embryos with normal chromosomes is significantly reduced and incidence of sex chromosome trisomies and autosomal monosomies and trisomies is increased; a tendency to decrease has been found for the frequency of male embryos. The obtained data may be useful to establish additional criteria for preimplantation genetic screening in the case of male infertility.
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Original Russian Text © Yu.Yu. Kiseleva, M.M. Azova, T.A. Kodyleva, A.O. Kirillova, A.N. Ekimov, A.S. Rakitko, N.G. Mishieva, A.N. Abubakirov, 2017, published in Genetika, 2017, Vol. 53, No. 12, pp. 1458–1462.
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Kiseleva, Y.Y., Azova, M.M., Kodyleva, T.A. et al. The increase in aneuploidy of embryos Is associated with pathological morphology of the sperm. Russ J Genet 53, 1378–1381 (2017). https://doi.org/10.1134/S1022795417120055
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DOI: https://doi.org/10.1134/S1022795417120055