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Variability and identification power of 60 X-chromosome in two native Siberian populations

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Abstract

Genetic diversity of 60 X-chromosome single nucleotide polymorphisms (XSNPid panel) in populations of Siberian Tatars and Tuvinians is described. A close spectrum of allele frequencies and a low level of their genetic differentiation (G st = 0.021) is revealed. High discriminating power of the XSNPid panel in populations under study is demonstrated. The random matching probability (MP) of multilocus genotypes in males is 1.12 × 10–18 in Siberian Tatars and 7.77 × 10–16 in Tuvans. In females, MP is several orders of magnitude lower: 1.51 × 10–25 in Siberian Tatars and 1.83 × 10–23 in Tuvinians.

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References

  1. Yang, Y., Xie, B., and Yan, Y., Application of next-generation sequencing technology in forensic science, Genomics, Proteomics Bioinf., 2014, vol. 12, pp. 190–197.

    Article  Google Scholar 

  2. Churchill, J.D., Chang, J., Ge, J., et al., Blind study evaluation illustrates utility of the Ion PGM system for use in human identity DNA typing, Croat. Med. J., 2015, vol. 56, pp. 218–229.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Krawczak, M., Informativity assessment for biallelic single nucleotide polymorphisms, Electrophoresis, 1999, vol. 20, pp. 1676–1681.

    Article  CAS  PubMed  Google Scholar 

  4. Li, C., Zhang, S., Zhao, S., et al., Analysis of 14 highly informative SNP markers on X chromosome by TaqMan SNP genotypoing assay, Forensic Sci. Int.: Genet., 2010, vol. 4, pp. e145–e148.

    Article  CAS  Google Scholar 

  5. Tomas, C., Sanchez, J.J., Castro, J.A., et al., Forensic usefulness of a 25 X-chromosome single-nuleotide polymorphism set, Transfusion, 2010, vol. 50, pp. 2258–2265.

    Article  CAS  PubMed  Google Scholar 

  6. Pereira, V., Tomas, C., Amorim, A., et al., Study of 25 X-chromosome SNPs in Portugu ese, Forensic Sci. Int.: Genet., 2011, vol. 5, no. 4, pp. 336–338.

    Article  CAS  Google Scholar 

  7. Vagaitseva, K.V., Khar’kov, V.N., Cherpinskaya, K.V., et al., Genetic variability of X-linked STR markers in Siberian populations, Mol. Biol. (Moscow), 2015, vol. 49, no. 2, pp. 267–274.

    Article  CAS  Google Scholar 

  8. Stepanov, V.A., Vagaitseva, K.V., and Kharkov, V.N., Multiplex X-SNP system for forensic genetics, in Program and Abstracts: 9th ISABS Conference on Forensic, Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine, Bol, Island of Brac, 2015, p. 86.

    Google Scholar 

  9. Stepanov, V.A. and Trifonova, E.A., Multiplex SNP genotyping by MALDI-TOF mass spectrometry: frequencies of 56 immune response gene SNPs in human populations, Mol. Biol. (Moscow), 2013, vol. 47, no. 6, pp. 852–862.

    Article  CAS  Google Scholar 

  10. Excoffier, L., Laval, G., and Schneider, S., Arlequin ver. 3.0: an integrated software package for population genetics data analysis, Evol. Bioinf. Online, 2005, vol. 1, pp. 47–50.

    CAS  Google Scholar 

  11. Barrett, J.C., Fry, B., Maller, J., and Daly, M.J., Haploview: analysis and visualization of LD and haplotype maps, Bioinformatics, 2005, vol. 21, no. 2, pp. 263–265.

    Article  CAS  PubMed  Google Scholar 

  12. Stepanov, V.A., Etnogenomika naseleniya Severnoi Evrazii (Population Ethnogenomics of Northern Eurasia), Tomsk: Pechatnaya manufaktura, 2002.

    Google Scholar 

  13. Stepanov, V.A., Khar’kov, V.N., Trifonova, E.A., and Marusin, A.V., Metody statisticheskogo analiza v populyatsionnoi i evolyutsionnoi genetike cheloveka: uchebnometodicheskoe posobie (Methods of Statistical Analysis in Human Population and Evolutionary Genetics: Study Guide), Tomsk: Pechatnaya manufaktura, 2014.

    Google Scholar 

  14. Stepanov, V.A., Balanovsky, O.P., Melnikov, A.V., et al., Characteristics of populations of the Russian Federation over the panel of fifteen loci used for DNA identification and in forensic medical examination, Acta Nat., 2011, vol. 3, no. 2, pp. 59–71.

    Google Scholar 

  15. Stepanov, V.A., Melnikov, A.V., Lash-Zavada, A.Y., et al., Genetic variability of 15 autosomal STR loci in Russian populations, Legal Med., 2010, vol. 12, no. 5, pp. 256–258.

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Research Institute for Medical Genetics, Tomsk, 634050, Russia

    V. A. Stepanov, K. V. Vagaitseva, V. N. Kharkov, A. A. Cherednichenko, L. I. Minaicheva & A. V. Bocharova

  2. National Research Tomsk State University, Tomsk, 634050, Russia

    V. A. Stepanov, K. V. Vagaitseva & V. N. Kharkov

Authors
  1. V. A. Stepanov
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  2. K. V. Vagaitseva
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  3. V. N. Kharkov
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  4. A. A. Cherednichenko
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  5. L. I. Minaicheva
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  6. A. V. Bocharova
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Corresponding author

Correspondence to V. A. Stepanov.

Additional information

Original Russian Text © V.A. Stepanov, K.V. Vagaitseva, V.N. Kharkov, A.A. Cherednichenko, L.I. Minaicheva, A.V. Bocharova, 2016, published in Genetika, 2016, Vol. 52, No. 4, pp. 493–496.

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Stepanov, V.A., Vagaitseva, K.V., Kharkov, V.N. et al. Variability and identification power of 60 X-chromosome in two native Siberian populations. Russ J Genet 52, 433–435 (2016). https://doi.org/10.1134/S1022795416030157

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  • DOI: https://doi.org/10.1134/S1022795416030157

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