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Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development

  • Human Genetics
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Abstract

Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP-1 (rs1799750, rs494379), MMP-2 (rs2285052), MMP-3 (rs3025058), MMP-9 (rs3918242, rs17576), and MMP-12 (rs2276109) and their tissue inhibitors TIMP-2 (rs8179090) and TIMP-3 (rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP-1, rs3025058 of gene MMP-3, rs3918242 and rs17576 of gene MMP-9, and rs9619311 of gene TIMP-3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.

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References

  1. Konturek, S.J., Helicobacter pylori and Its Involvement in Gastritis and Peptic Ulcer Formation, Konturek, S.J. and Konturek, P.C., Eds., J. Physiol. Pharmacol., 2006, vol. 57, no. 3, pp. 29–50.

    PubMed  Google Scholar 

  2. Zelickson, M.S., Bronder, C.M., Johnson, B.L., et al., Helicobacter pylori is not the predominant etiology for peptic ulcers requiring operation, Am. Surg., 2011, vol. 77, pp. 1054–1060.

    PubMed  Google Scholar 

  3. Bertleff, M.J. and Lange, J.F., Perforated peptic ulcer disease: a review of history and treatment, Dig. Surg., 2010, vol. 27, pp. 161–169.

    Article  PubMed  Google Scholar 

  4. Lau, J.Y., Sung, J., Hill, C., et al., Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality, Digestion, 2011, vol. 84, pp. 102–113.

    Google Scholar 

  5. http://wwwmednetru

  6. Baranovskii, A.Yu., Gastroenterologiya: spravochnik (Gastroenterology: Reference Book), Baranovskii, A.Yu., Ed., St. Petersburg: Piter, 2011.

  7. Go, M.F., Natural history and epidemiology of Helicobacter pylori infection, Aliment. Pharmacol. Ther., 2002, vol. 16, pp. 3–15.

    Article  PubMed  Google Scholar 

  8. Aljamal, A., Effects of turmeric in peptic ulcer and Helicobacter pylori, Plant Sci. Res., 2011, vol. 3, pp. 25–28.

    Google Scholar 

  9. Snaith, A. and El-Omar, E.M., Helicobacter pylori: host genetics and disease outcomes, Expert Rev. Gastroenterol. Hepatol., 2008, vol. 2, no. 4, pp. 577–585.

    Article  CAS  PubMed  Google Scholar 

  10. Pasieshvili, L.M. and Morgulis, M.V., State and role of cytokines in formation and progression of diseases of the alimentary channel, Suchasna Gastroenterol., 2004, no. 3, pp. 8–11.

    Google Scholar 

  11. Tsaregorodtseva, T.M., Zotina, M.M., and Serova, T.I., Interleukins in chronic diseases of digestive organs, Ter. Arkh., 2003, no. 2, pp. 7–9.

    Google Scholar 

  12. Mathew, C.C., The isolation of high molecular weight eukaryotic DNA, Methods Mol. Biol., 1984, vol. 2, pp. 31–34.

    CAS  Google Scholar 

  13. Santtila, S., Savinainen, K., Hurme, M., et al., Presence of the IL-1RA allele 2 (IL-1RN*2) is aßsociated with enhanced IL-1ß production in vitro, Scand. J. Immunol., 1998, vol. 47, pp. 195–198.

    Article  CAS  PubMed  Google Scholar 

  14. Hull, J., Ackerman, H., Isles, K., et al., Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus, Am. J. Hum. Genet., 2001, vol. 69, pp. 413–419.

    CAS  PubMed  Google Scholar 

  15. Karplus, T.M., Jeronimo, S.M., Chang, H., et al., Association between the tumor necrosis factor locus and the clinical outcome the Leishmania chagasi infection, Infect. Immun., 2002, vol. 70, no. 12, pp. 6919–6925.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Hang, L.W., Hsia, T.C., Chen, W.C., et al., Interleukin10 gene–627 allele variants, not interleukin-I beta gene and receptor antagonist gene polymorphisms, are associated with atopic bronchial asthma, J. Clin. Lab. Anal., 2003, vol. 17, no. 5, pp. 168–173.

    CAS  PubMed  Google Scholar 

  17. Schlesselman, J., Case-Control Studies: Design, Conduct, Analysis, New York: Oxford Univ. Press, 1982, pp. 58–96.

    Google Scholar 

  18. Abramson, J.H., WINPEPI updated: computer programs for epidemiologists, and their teaching potential, Epidemiol. Perspect. Innovations, 2011, vol. 8, pp. 1–9.

    Article  Google Scholar 

  19. Higgins, J.P. and Thompson, S.G., Quantifying heterogeneity in a meta-analysis, Stat. Med., 2002, vol. 21, pp. 1539–1558.

    Article  PubMed  Google Scholar 

  20. Lou, X.Y., Chen, G.B., Yan, L., et al., A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence, Am. J. Hum. Genet., 2007, vol. 80, no. 6, pp. 1125–1137.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Saarialho-Kere, U.K., Vaalamo, M., Puolakkainen, P., et al., Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers, Am. J. Pathol., 1996, vol. 148, pp. 519–526.

    CAS  PubMed  Google Scholar 

  22. Bobkova, I.N., Kozlovskaya, L.V., and Li, O.A., Matrix metalloproteinases in the pathogenesis of acute and chronic kidney disease (review of literature), Nefrol. Dializ, 2010, vol. 10, no. 2, pp. 105–111.

    Google Scholar 

  23. Cheng, H.-C., Yang, H.-B., Chang, W.-L., et al., Expression of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers, Sci. World J., 2012, pp. 1–9.

    Google Scholar 

  24. Tomita, M., Ando, T., Minami, M., et al., Potential role for matrix metalloproteinase-3 in gastric ulcer healing, Digestion, 2009, vol. 79, pp. 23–29.

    Article  CAS  PubMed  Google Scholar 

  25. Yeh, Y.-Ch., Cheng, H.-Ch., Chang, W.-L., et al., Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females, Microbiology, 2010, vol. 10, pp. 218–225.

    PubMed  PubMed Central  Google Scholar 

  26. Dey, S., Stalin, S., Gupta, A., et al., Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are associated with gastric cancer risk in Eastern Indian population, Mol. Carcinog., 2011, vol. 51, pp. 1–12.

    Google Scholar 

  27. Kim, S-J., Park, Y.S., Paik, H.D., et al., Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers, Br. J. Nutr., 2011, vol. 106, pp. 1792–1801.

    Article  CAS  PubMed  Google Scholar 

  28. Yang, T.-F., Guo, L., and Wang, Q., Meta-analysis of association between for polymorphisms in the matrix metalloproteinases gene in gastric cancer risk, Asian Pac. J. Cancer Prev., 2014, vol. 15, no. 3, pp. 1263–1267.

    Article  PubMed  Google Scholar 

  29. Matsumura, S., Oue, N., Nakayama, H., et al., A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer, J. Cancer Res. Clin. Oncol., 2005, vol. 131, pp. 19–25.

    Article  CAS  PubMed  Google Scholar 

  30. Lin, X.D., Chen, G., Li, C., et al., Association of polymorphism in matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 with genetic susceptibility of gastric cancer, Chin. J. Prev. Med., 2011, vol. 45, no. 8, pp. 711–716.

    CAS  Google Scholar 

  31. Zheng, J., Chu, D., Wang, D., et al., Matrix metalloproteinase-12 is associated with overall survival in Chinese patients with gastric cancer, J. Surg. Oncol., 2013, vol. 107, no. 7, pp. 746–751.

    Article  CAS  PubMed  Google Scholar 

  32. Li, S., Zhou, W., Assomaning, A., et al., Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer, Carciogenesis, 2006, vol. 27, pp. 1024–1029.

    Google Scholar 

  33. Haq, I., Chappel, S., Johnson, S.R., et al., Association of MMP-12 polymorphisms with severe and very severe COPD: a case control study of MMPs-1,9 and 12 in a European population, BMC Med. Genet., 2010, vol. 11, pp. 1–11.

    Article  Google Scholar 

  34. Perez-Hernandes, N., Vargas-Alarcon, G., MartinazRodrigues, N., et al., The matrix metalloproteinase-2— 1575 gene polymorphisms is associated with the risk of developing myocardial infarction in Mexican patients, J. Atheroscler. Thromb., 2012, vol. 19, pp. 718–727.

    Article  Google Scholar 

  35. Ramnath, N. and Creaven, P.J., Matrix metalloproteinase inhibitors, Curr. Oncol. Rep., 2004, vol. 6, no. 2, pp. 96–102.

    Article  PubMed  Google Scholar 

  36. Murphy, G. and Nagase, H., Progress in matrix metalloproteinase research, Mol. Aspects Med., 2008, vol. 29, no. 5, pp. 290–308.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Sounni, N.E., Janssen, M., Foidart, J.M., and Noel, A., Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis, Matrix Biol., 2003, vol. 22, no. 1, pp. 55–61.

    Article  CAS  PubMed  Google Scholar 

  38. Brew, K., Dinakarpandian, D., and Nagase, H., Tissue inhibitors of metallo-proteinases: evolution, structure and function, Biochim. Biophys. Acta, 2000, vol. 1477, pp. 267–283.

    Article  CAS  Google Scholar 

  39. Wieczorek, E., Reszka, E., Jablonowski, Z., et al., Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility, BJU Int., 2013, vol. 8, pp. 1207–1214.

    Google Scholar 

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Authors and Affiliations

  1. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, 450076, Russia

    E. Kh. Shaymardanova, A. Kh. Nurgalieva, I. M. Khidiyatova & E. Kh. Khusnutdinova

  2. Department of Polyclinic Therapy, Bashkir State Medical University, Ufa, 450000, Russia

    L. V. Gabbasova, O. A. Kuramshina & A. Ya. Kryukova

  3. Emergency Hospital, Ufa, 450000, Russia

    R. B. Sagitov

  4. Republican Clinical Oncological Dispensary, Ufa, 450000, Russia

    F. R. Munasipov

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  1. E. Kh. Shaymardanova
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  2. A. Kh. Nurgalieva
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  3. I. M. Khidiyatova
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  4. L. V. Gabbasova
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  6. A. Ya. Kryukova
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  9. E. Kh. Khusnutdinova
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Correspondence to E. Kh. Shaymardanova.

Additional information

Original Russian Text © E.Kh. Shaymardanova, A.Kh. Nurgalieva, I.M. Khidiyatova, L.V. Gabbasova, O.A. Kuramshina, A.Ya. Kryukova, R.B. Sagitov, F.R. Munasipov, E.Kh. Khusnutdinova, 2016, published in Genetika, 2016, Vol. 52, No. 3, pp. 364–375.

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Shaymardanova, E.K., Nurgalieva, A.K., Khidiyatova, I.M. et al. Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development. Russ J Genet 52, 320–330 (2016). https://doi.org/10.1134/S1022795416020113

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  • DOI: https://doi.org/10.1134/S1022795416020113

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