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Association of kynurenine-3-monooxygenase gene with schizophrenia

  • Human Genetics
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Abstract

Neurotoxic products produced during tryptophan metabolism via the kynurenine pathway could be involved in schizophrenia pathogenesis. It has been shown that kynurenine-3-monooxygenase (KMO) is indirectly involved in these products’ formation. KMO polymorphic loci rs2275163 (C/T) and rs1053230 (A/G) were examined in 187 schizophrenia patients and 229 healthy subjects. A genetic combination of allele T and genotype GG was observed more often in a patient group compared with healthy controls (p = 0.003, OR 2.0 (95% CI 1.2–2.9)). In the latter group, this combination was associated with schizophrenia endophenotype (p = 0.04), which manifested in a higher expression of schizotypal personality traits assessed using the MMPI test.

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Authors and Affiliations

  1. Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 115522, Russia

    V. E. Golimbet, T. V. Lezheiko, M. V. Alfimova, L. I. Abramova & N. V. Kondrat’ev

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  1. V. E. Golimbet
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  2. T. V. Lezheiko
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  3. M. V. Alfimova
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  4. L. I. Abramova
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  5. N. V. Kondrat’ev
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Correspondence to V. E. Golimbet.

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Original Russian Text © V.E. Golimbet, T.V. Lezheiko, M.V. Alfimova, L.I. Abramova, N.V. Kondrat’ev, 2014, published in Genetika, 2014, Vol. 50, No. 6, pp. 724–728.

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Golimbet, V.E., Lezheiko, T.V., Alfimova, M.V. et al. Association of kynurenine-3-monooxygenase gene with schizophrenia. Russ J Genet 50, 634–637 (2014). https://doi.org/10.1134/S1022795414060039

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  • DOI: https://doi.org/10.1134/S1022795414060039

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