A level of X-ray induced mitotic disturbances in the cells of the bone marrow of male mice was studied under the modifying influence of chemosignals from isolated adult female mice of the CBA strain. It has been shown that the frequency of chromosomal aberrations in irradiated (4 Gr) males after exposing them for 24 hours on bedding soiled with female chemosignals is lower than in irradiated males in cages with clean bedding. The mechanisms and importance of the antimutagenic effect of female house mouse chemosignals are discussed.
This is a preview of subscription content,to check access.
Access this article
Koyama, S., Primer effects by conspecific odors in house mice: a new perspective in the study of primer effects on reproductive activities, Horm. Behav., 2004, vol. 46, pp. 303–310.
Tirindelli, R., Dibattista, M., Pifferi, S., and Menini, A., From pheromones to behavior, Physiol. Rev., 2009, vol. 89, no. 3, pp. 921–956.
Daev, E.V., Glinin, T.S., and Dukelskaya, A.V., Pheromones and adaptive bystander-mutagenesis in mice, in Radiobiology and Environmental Security, Mothersill, C.E., Korogodina, V., and Seymour, C.B., Eds., Dordrecht: Springer-Verlag, 2011, pp. 153–162.
Daev, E.V., Genetic aspects of stress neuroendocrinology, in Neuroendocrinology Research Developments, Penkava, N.S. and Haight, L.R., Eds., Hauppauge: Nova Science, 2010, pp. 119–133.
Daev, E.V., Glinin, T.S., and Dukelskaya, A.V., The role of social factors in the regulation of stability of the cell genetic machinery in animals, Dokl. Biochem. Biophys., 2010, vol. 435, pp. 299–301.
Daev, E.V., Glinin, T.S., and Dukelskaya, A.V., The balance hypothesis of the effect of socially important volatile chemosignals on reactivity of chromosome machinery of bone marrow dividing cells in the house mouse Mus musculus L., J. Evol. Biochem. Physiol., 2012, vol. 48, no. 3, pp. 280–286.
Kelliher, K.R. and Wersinger, S.R., Olfactory regulation of the sexual behavior and reproductive physiology of the laboratory mouse: effects and neural mechanisms, ILAR J. NRC, 2008, vol. 50, no. 1, pp. 28–42.
Daev, E.V. Genetic Effects of Olfactory Stresses: Research of House Mice, Saarbrucken: Lambert Acad. Publ., 2011.
Daev, E.V. and Dukel’skaya, A.V., Induction of meiotic disturbances in spermatocytes I by pheromones as an inhibiting mechanism of male reproductive function in house mice, Tsitologiya, 2005, vol. 47, no. 6, pp. 505–509.
Schellinck, H.M., Smyth, C., Brown, R.E., and Wilkinson, M., Odor-induced sexual maturation and expression of c-fos in the olfactory system of juvenile female mice, Brain Res. Dev. Brain Res., 1993, vol. 74, pp. 138–141.
Veyrac, A., Wang, G., Baum, M.J., and Bakker, J., The main and accessory olfactory systems of female mice are activated differentially by dominant versus subordinate male urinary odors, Brain Res., 2011, vol. 1402, pp. 20–29.
Daev, E.V., Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.), Russ. J. Genet., 1994, vol. 30, no. 8, pp. 964–970.
Daev, E.V., Sverdlova, O.L., Matskevich, O.A., and Antonyuk, E.V., Cytogenetic effect of pheromones on bone marrow cells of male house mice (Mus musculus L.), Russ. J. Genet., 1995, vol. 31, no. 5, pp. 541–544.
Daev, E.V. and Poluekhina, E.V., Cytogenetic effect of volatile components of urine of mature animals on bone marrow cells of young female house mice Mus musculus L., Russ. J. Genet., 1996, vol. 32, no. 3, pp. 357–360.
Daev, E.V. and Sverdlova, O.L., Analysis for pheromone-induced cytogenetic disturbances depending on major urinary proteins of laboratory mouse males, Russ. J. Genet., 2002, vol. 38, no. 2, pp. 132–137.
Novikov, S.N., Tsapygina, R.I., Daev, E.V., and Togo, E.F., Effect of natural compounds of biogenic origin on the behavior and generative function of male house mice, Mus musculus L., Dokl. Akad. Nauk SSSR, 1982, vol. 262, no. 3, pp. 746–747.
Novikov, S.N., Daev, E.V., and Tsapygina, R.I., Action of the volatile components of the urine on the generative function of sexually immature male house mice Mus musculus L., Dokl. Akad. Nauk SSSR, 1985, vol. 281, no. 6, pp. 1506–1508.
Daev, E.V., Stress, chemocommunication, and the physiological hypothesis of mutation, Russ. J. Genet., 2007, vol. 43, no. 10, pp. 1082–1092.
Daev, E.V., Surinov, B.P., Dukel’skaya, A.V., and Marysheva, T.M., Chromosomal abnormalities and spleenocyte production in laboratory mouse males after exposure to stress chemosignals, Cell Tissue Biol., 2007, vol. 49, no. 8, pp. 696–701.
Jemiolo, B. and Novotny, M., Inhibition of sexual maturation in juvenile female and male mice by chemosignal of female origin, Physiol. Behav., 1994, vol. 55, pp. 519–522.
Mugford, R.A. and Nowell, N.W., Pheromones and their effect on aggression in mice, Nature, 1970, vol. 226, pp. 967–968.
Mugford, R.A. and Nowell, N.W., Endocrine control over production and activity of the anti-aggression pheromone from female mice, J. Endocrinol., 1971, vol. 49, pp. 225–232.
Maruniak, J.A. and Bronson, F.H., Gonadotropic responses of male mice to female urine, Endocrinology, 1976, vol. 99, no. 4, pp. 963–969.
Maruniak, J.A., Coquelin, A., and Bronson, F.H., The release of LH in male mice in response to female urinary odors: characteristics of the response in young males, Biol. Reprod., 1978, vol. 18, no. 2, pp. 251–255.
Litvinova, E.A., Goncharova, E.P., Zaydman, A.M., et al., Female scent signals enhance the resistance of male mice to influenza, PLoS One, 2010, vol. 5, no. 3, p. e9473.
Surinov, B.P and Isaeva, V.G., Immunomodulation effects volatile secretion of animals at postradiation immunodeficiency conditions, Radiats. Biol., Radioekol., 2008, vol. 48, no. 6, pp. 665–670.
Daev, E.V., Kazarova, V.E., Vyborova, A.M., and Dukelskaya, A.V., Effects of “pheromone-like” pyrazine-containing compounds on stability of genetic apparatus in bone marrow cells of the male house mouse, Mus musculus L., J. Evol. Biochem. Physiol., 2009, vol. 45, no. 5, pp. 589–595.
Glotov, N.V., Zhivotovskii, L.A., Khovanov, N.V., and Khromov-Borisov, N.N., Biometriya, (Biometry), Leningrad: Leningrad Gos. Univ., 1982.
Lobashev, M.E., Ponomarenko, V.V., Polyanskaya, G.G., and Tsapygina, R.I., On the role of nervous system in regulation of various genetic and cytological processes, Zh. Evol. Biokhim. Fiziol., 1973, vol. 9, no. 4, pp. 396–406.
Lopatina, N.G., Ponomarenko, V.V., and Smirnova, G.P., Hypothesis of nervous regulation of the process of genetic information realization, in Problemy vysshei nervnoi deyatel’nosti i neirofiziologii (Problems of Higher Nervous Activity and Neurophysiology), Leningrad: Nauka, 1975, pp. 107–121.
Kerkis, Yu.Ya. and Skorova, S.V., On factors, controlling the spontaneous mutation process, Inf. Byull. Nauch. Sov. Probl. Radiobiol., 1977, no. 20, pp. 51–52.
Kerkis, Yu.Ya., Osetrova, G.D., Loginova, V.V., et al., Genetic and physiological (humoral) factors, controlling the induced and spontaneous mutation process in mammals, in Problemy teoreticheskoi i prikladnoi genetiki (Problems in Theoretical and Applied Genetics), Novosibirsk, 1973, pp. 75–94.
Dyuzhikova, N.A., Bykovskaya, N.V., Vaido, A.I., et al., Rate of chromosomal aberrations induced by short-term stress in rats selected for excitability of the nervous system, Russ. J. Genet., 1996, vol. 32, pp. 851–853.
Sacharczuk, M., Jaszczak, K., and Sadowski, B., Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia, Mutat. Res., Genet. Toxicol. Environ. Mutagen., 2003, vol. 535, no. 1, pp. 95–102.
Borodin, P.M. and Belyaev, D.K., The influence of stress on crossing over frequency in the second chromosome of house mouse, Dokl. Akad. Nauk SSSR, 1980, vol. 253, no. 3, pp. 727–729.
Dyuzhikova, N.A., Savenko, Yu.N., Vaido, A.I., et al., Changes in the heterochromatin hippocampal neurons’ state under conditions of post-traumatic stress disorder modeling depends on characteristics of nervous system excitability, Zh. EKO, 2003, nos. 10–11, pp. 67–68.
Opol’skii, A.F., The influence of the hypothalamus on mutagenesis in somatic cells of animals, in Chuvstvitel’nost’ organizmov k mutagennym faktoram i vozniknovenie mutatsii (The Sensitivity of Organisms to Mutagenic Factors and Appearance of Mutations), Vilnus: Vilnus Gos. Univ., 1982, pp. 20–21.
Seredenin, S.B., Durnev, A.D., and Vedernikova, A.A., Effect of emotional stress on the frequency of chromosomal aberrations in mouse bone marrow cells, Byull. Eksp. Biol. Med., 1980, no. 7, pp. 91–92.
Azzam, E.I., de Toledo, S.M., and Little, J.B., Stress signaling from irradiated to non-irradiated cells, Curr. Cancer Drug Targets, 2004, vol. 4, pp. 53–64.
Hei, T.K., Zhou, H., Ivanov, V.N., et al., Mechanism of radiation-induced bystander effects: a unifying model, JPP, 2008, vol. 60, pp. 943–950.
Vaido, A.I., Dyuzhikova, N.A., Shiryaeva, N.V., et al., Systemic control of the molecular, cell, and epigenetic mechanisms of long-lasting consequences of stress, Russ. J. Genet., 2009, vol. 45, no. 3, pp. 298–303.
Nersesyan, A.K., Boffetta, P., Sarkisyan, T.F., et al., Chromosome aberrations in lymphocytes of persons exposed to an earthquake in Armenia, Scand. J. Work, Environ. Health, 2001, vol. 27, no. 2, pp. 120–124.
Koterov, A.N. and Biryukov, A.P., The possibility of determining of anomalies and pathologies in the off-spring of liquidators of Chernobyl accident by non-radiation factors, Int. J. Low Radiat. (IJLR), 2011, vol. 8, no. 4, pp. 256–312.
Daev, E.V., The effect of exogenous metabolites on cytogenetic characteristics of spermatogenesis and reproductive function of house mouse males, Cand. Sci. (Biol.) Dissertation, Leningrad: Leningrad State Univ., 1983.
Tsapygina, R.I., Daev, E.V., and Novikov, S.N., The influence of exogenous metabolites of house mouse males on the cell proliferation process in generative tissues of young animals after single and multiple treatments, Issled. Genet., 1981, no. 9, pp. 17–23.
Kohl, J.V., Atzmueller, M., Fink, B., and Grammer, K., Human pheromones: integrating neuroendocrinology and ethology, Neuroendocrinol. Lett., 2001, vol. 22, pp. 309–321.
Ziegler, A., Dohr, G., and Uchanska-Ziegler, B., Possible roles for products of polymorphic MHC and linked olfactory receptor genes during selection processes in reproduction, Am. J. Reprod. Immunol., 2002, vol. 48, pp. 34–42.
Original Russian Text © E.V. Daev, T.S. Glinin, A.V. Dukelskaya, 2014, published in Genetika, 2014, Vol. 50, No. 1, pp. 62–68.
About this article
Cite this article
Daev, E.V., Glinin, T.S. & Dukelskaya, A.V. Chemosignals from isolated females have antimutagenic effect in dividing the cells of bone marrow from male mice of the CBA strain. Russ J Genet 50, 55–60 (2014). https://doi.org/10.1134/S1022795414010037