Abstract
The distribution of the allele and genotype frequency for the TOMM40 gene polymorphic variants rs741780, rs157580, rs1160985, rs2075650, and rs8106922 was analyzed in a sampling of ethnic Russians from the city of Kemerovo. The study of the structure of linkage disequilibrium in terms of five studied polymorphic variants showed the presence of a haplotype block 2 Kb in length, which includes three polymorphic variants, i.e., rs741780, rs1160985, and rs8106922. The differences in the frequencies of alleles and genotypes in terms of the polymorphic rs2075650 and rs157580 variants between ethnic Russians from the city of Kemerovo and other European populations were detected. It was discovered that polymorphic variants of TOMM40 rs741780, rs1160985, and rs8106922 are associated with serum triglyceride concentrations. In men, the polymorphic variant rs2075650 is associated with low-density lipoprotein cholesterol levels. In women, the polymorphic variant rs741780 is associated with diastolic blood pressure levels.
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Johnson, S.C., LaRue, A., Hermann, B.P., et al., The effect of TOMM40 poly-T length on grey matter volume and cognition in middle-aged persons with APOE ɛ3/ɛ3 genotype, Alzheimer’s Dementia, 2011, vol. 7, pp. 456–465.
Lutz, M.W., Crenshaw, D.G., Saunders, A.M., and Roses, A.D., Genetic variation at a single locus and age of onset for Alzheimer’s disease, Alzheimer’s Dementia, 2010, vol. 6, pp. 125–131.
Roses, A.D., An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer’s disease, Arch. Neurol., 2010, vol. 67, no. 5, pp. 536–541.
Aulchenko, Y.S., Ripatti, S., Lindqvist, I., et al., Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts, Nat. Genet., 2009, no. 41, pp. 47–55.
Middelberg, R.P., Ferreira, M.A., Henders, A.K., et al., Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits, BMC Med. Genet., 2011, no. 12.
Sandhu, M.S., Waterworth, D.M., Debenham, S.L., et al., LDL-cholesterol concentrations: a genome-wide association study, Lancet, 2008, vol. 371, no. 9611, pp. 483–491.
Schupf, N., Barral, S., Perls, T., et al., Apolipoprotein E and familial longevity, Neurobiol. Aging, 2013, vol. 34, no. 4, pp. 1287–1291.
Talmud, P.J., Drenos, F., Shah, S., et al., Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVDBeadChip, Am. J. Hum. Genet., 2009, no. 85, pp. 628–642.
Zhang, Z., Tao, L., Chen, Z., et al., Association of genetic loci with blood lipids in the Chinese population, PLoS One, 2011, vol. 6, no. 11.
Maniatis, T., Fritsch, E.F., and Sambrook, J., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor: Cold Spring Harbor Lab., 1982.
Weir, B.S., Genetic Data Analysis: Method for Discrete Population Genetic Data, Sunderland: Sinauer Associates, 1990.
Lambert, J.C., Heath, S., Even, G., et al., Genomewide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease, Nat. Genet., 2009, no. 41, pp. 1094–1099.
Potkin, S.G., Guffanti, G., Lakatos, A., et al., Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer’s disease, PLoS One, 2009, vol. 4, no. 8.
Clark, D., Skrobot, O.A., Adebiyi, I., et al., Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients, Eur. Psychiatry, 2009, no. 24, pp. 456–463.
Guo, Y., Lanktree, M.B., Taylor, K.C., et al., Genecentric meta-analyses of 108912 individuals confirm known body mass index loci and reveal three novel signals, Hum. Mol. Genet., 2013, vol. 22, no. 1, pp. 184–201.
Chiba-Falek, O., Linnertz, C., Guyton, J., et al., Pleiotropy and allelic heterogeneity in the TOMM40APOE genomic region related to clinical and metabolic features of hepatitis C infection, Hum. Genet., 2012, vol. 131, no. 12, pp. 1911–1920.
Bekris, L.M., Lutz, F., and Yu, C.E., Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE, Hum. Genet., 2012, vol. 57, no. 1, pp. 18–25.
Roses, A.D., Lutz, M.W., Amrine-Madsen, H., et al., A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer’s disease, Pharmacogenomics J., 2010, vol. 10, pp. 375–384.
Devi, L., Prabhu, B.M., Galati, D.F., et al., Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer’s disease brain is associated with mitochondrial dysfunction, J. Neurosci., 2006, vol. 26, no. 35, pp. 9057–9068.
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Original Russian Text © R.R. Salakhov, I.A. Goncharova, O.A. Makeeva, M.V. Golubenko, E.V. Kulish, V.V. Kashtalap, O.L. Barbarash, V.P. Puzyrev, 2014, published in Genetika, 2014, Vol. 50, No. 2, pp. 222–229.
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Salakhov, R.R., Goncharova, I.A., Makeeva, O.A. et al. TOMM40 gene polymorphisms association with lipid profile. Russ J Genet 50, 198–204 (2014). https://doi.org/10.1134/S1022795413120090
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DOI: https://doi.org/10.1134/S1022795413120090