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Association of YWHAE gene polymorphism with suicidal behavior

  • Human Genetics
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Abstract

The importance of YWHAE gene polymorphisms (rs1532976, rs3752826, and rs9393) in the development of suicidal behavior has been studied in ethnic groups of Russians and Tatars from the Republic of Bashkortostan. It was revealed that the carriers of the YWHAE*C allele of rs3752826 polymorphism of the YWHAE gene have increased the risk of suicidal behavior (OR = 1.91), regardless of their ethnicity. In addition, the YWHAE*T allele of rs9393 polymorphism (OR = 2.21), YWHAE*T/*T genotype (OR = 2.73), and YWHAE*T allele (OR = 1.52) of the rs1532976 polymorphism, as well as the YWHAE*A*T haplotype of rs1532976 and rs9393 polymorphisms (OR = 1.54) represent genetic markers of the risk of suicidal behavior in the sample of subjects of Russian ethnicity.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, 450054, Russia

    Z. L. Khalilova, A. G. Zainullina & E. K. Khusnutdinova

  2. Department of Genetics and Fundamental Medicine of Bashkir State University, Ufa, 450054, Russia

    A. R. Valiullina & E. K. Khusnutdinova

  3. Bashkir Republic Psychiatric Hospital No. 1, Ufa, 450069, Russia

    G. G. Zakharova & R. G. Valinurov

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  1. Z. L. Khalilova
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  2. A. G. Zainullina
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  3. A. R. Valiullina
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  4. G. G. Zakharova
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  5. R. G. Valinurov
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  6. E. K. Khusnutdinova
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Correspondence to Z. L. Khalilova.

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Original Russian Text © Z.L. Khalilova, A.G. Zainullina, A. R. Valiullina, G.G. Zakharova, R.G. Valinurov, E.K. Khusnutdinova, 2013, published in Genetika, 2013, Vol. 49, No. 6, pp. 767–772.

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Khalilova, Z.L., Zainullina, A.G., Valiullina, A.R. et al. Association of YWHAE gene polymorphism with suicidal behavior. Russ J Genet 49, 667–672 (2013). https://doi.org/10.1134/S1022795413030095

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