Haplotype variation of estrogen receptor-α (ER-α) gene exon 4 in Turkish sheep breeds


Estrogen receptor a (ERα) gene has previously been found related with sexual development and reproduction. In this study, on the basis of the sequences of human, cattle and caprine estrogen receptor α (ERα) genes, available in the GenBank database, sets of PCR primers were designed and used to amplify the ovine ERα gene exon 4 region. We identified six single nucleotide polymorphisms (SNP) in the ERα exon 4. Some variations determined for exon 4 g.43A > G, p.T43A; g.49C > T, p.L49F; g.178A > T, p.T178S led to changes in the amino acids, but no amino acid changes were determined in g.18G > C, g.27C > T, g.96G > A. These fragments were deposited in the GenBank database under accession numbers: JF262030-JF262035. It was noted in particular that White Karaman and Awassi breeds were similar to each other, whereas the Chios breed had a different variation.

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Ozmen, O., Seker, I., Cinar Kul, B. et al. Haplotype variation of estrogen receptor-α (ER-α) gene exon 4 in Turkish sheep breeds. Russ J Genet 48, 1015–1019 (2012). https://doi.org/10.1134/S1022795412100067

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  • Estrogen Receptor
  • Amino Acid Change
  • Single Nucleotide Polymorphism
  • Litter Size
  • Sort Intolerant From Tolerant