Skip to main content
SpringerLink
Log in

Association of rs10912745 and rs4916375 polymorphisms located in the cluster of flavin-containing monooxygenase genes, with ischaemic cardioembolic stroke

  • Short Communications
  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

Twenty-one SNPs located in the cluster of genes FMO1-FMO2-FMO3-FMO4 and adjacent areas were analyzed in the patients with ischaemic cardioembolic stroke and in the control group. Significant differences between these samples were found in the distribution of genotype and allele differences in two polymorphic loci, rs10912745 and rs4916375. It was shown that these polymorphic loci are associated with the risk of ischaemic cardioembolic stroke development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Gusev, E.I. and Skvortsova, V.I., Ishemiya golovnogo mozga (Brain Ischemia), Moscow: Meditsina, 2001.

    Google Scholar 

  2. Limborska, S.A., Slominsky, P.A., Bondarenko, E.A., et al., Genome Wide Association Study for Acute Stroke in Russians, The Biology of Genomes (Abstract of Papers Presented at the Meeting), Cold Spring Harbor, 2011, p. 173.

  3. Benedetti, M., FAD-Dependent Enzymes Involved in the Metabolic Oxidation of Xenobiotics, Ann. Pharm. Fr., 2011, vol. 69, no. 1, pp. 45–52.

    Article  Google Scholar 

  4. Dolphin, C.T., Beckett, D.J., Janmohamed, A., et al., The Flavin-Containing Monooxygenase 2 Gene (FMO2) of Humans, but Not of Other Primates, Encodes a Truncated, Nonfunctional Protein, J. Biol. Chem., 1998, vol. 273, no. 46, pp. 30599–30607.

    Article  PubMed  CAS  Google Scholar 

  5. Li, M., Al-Sarraf, A., Sinclair, G., and Frohlich, J., Fish Odour Syndrome, CMAJ., 2011, vol. 183, no. 8, pp. 929–931.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia

    T. V. Tupitsyna, E. A. Bondarenko, P. A. Slominsky & S. A. Limborska

  2. Pirogov Russian National Research Medical University, Moscow, 117415, Russia

    I. M. Shetova, N. A. Shamalov, D. Yu. Timofeev & V. I. Skvortsova

Authors
  1. T. V. Tupitsyna
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Bondarenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. A. Slominsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. M. Shetova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. A. Shamalov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. Yu. Timofeev
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. V. I. Skvortsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. A. Limborska
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. V. Tupitsyna.

Additional information

Original Russian Text © T.V. Tupitsyna, E.A. Bondarenko, P.A. Slominsky, I.M. Shetova, N.A. Shamalov, D.Yu. Timofeev, V.I. Skvortsova, S.A. Limborska, 2012, published in Genetika, 2012, Vol. 48, No. 5, pp. 672–675.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tupitsyna, T.V., Bondarenko, E.A., Slominsky, P.A. et al. Association of rs10912745 and rs4916375 polymorphisms located in the cluster of flavin-containing monooxygenase genes, with ischaemic cardioembolic stroke. Russ J Genet 48, 572–574 (2012). https://doi.org/10.1134/S1022795412040138

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1022795412040138

Keywords

Search

Navigation