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No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility

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Abstract

Brain-derived neurotrophic factor (BDNF) plays important roles in neuronal development and reproductive action. Abnormal expression of BDNF gene has been detected in human sperm and seminal serum. In the present study, we investigated the possible association of G196A and C270T polymorphism of BDNF gene with male infertility. The genotypes of the G196A and C270T polymorphisms were in Hardy-Weinberg equilibrium both in fertile and infertile group. The genotype distribution frequencies were similar between infertile and fertile group. The results showed that the G196A and C270T polymorphism of the BDNF gene is unrelated to the male infertility, at least in a Chinese population.

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Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, and Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, Jilin Province, 130062, China

    Ch. Li, Y. Sun, Ch. Wang, W. Li, Ch. Lu & X. Zhou

  2. Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, Jilin Province, 130062, China

    L. Zheng

  3. College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China

    Y. Sun

  4. Liaoning Medical University, Jinzhou, Liaoning Province, 121001, China

    Ch. Wang

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  1. Ch. Li
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  2. L. Zheng
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  3. Y. Sun
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  4. Ch. Wang
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  5. W. Li
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  6. Ch. Lu
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  7. X. Zhou
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Correspondence to X. Zhou.

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Li, C., Zheng, L., Sun, Y. et al. No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility. Russ J Genet 48, 350–352 (2012). https://doi.org/10.1134/S1022795412030076

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  • DOI: https://doi.org/10.1134/S1022795412030076

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