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The study of the SNP in the corticotropin-releasing hormone gene (Exon 2) and milk production traits in cattle

  • Animal Genetics
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Abstract

The aim of this study was estimate the relations between CRH C22G and milk production traits (milk yield, yield of protein and fat, content of protein and fat in milk). The study was carried on 169 Polish Holstein-Friesian strain Red-and-White cows kept in the south-western region of Poland. The CRH C22G (exon 2) polymorphisms were detected using PCR-RFLP method. The genotype and allele frequencies were estimated and they were as follows: CC—0.89, CG—0.09, GG—0.02; C—0.93, G—0.07. Statistically significant (P ≤ 0.05) associations between CRH C22G genotypes and milk production traits like milk yield and protein yield in the second lactation were found. Moreover, the obtained results should be verified by conducting research on a larger group of animals and various cattle breeds.

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References

  1. Aguilera, G., Corticotropin Releasing Hormone, Receptor Regulation and the Stress, Trends Endocrin. Met., 1998, vol. 9, pp. 329–336.

    Article  CAS  Google Scholar 

  2. Fukuda, Y., Kageyama, K., Nigawara, T., et al., Effects of Corticotropin-Releasing Hormone (CRH) on the Synthesis and Secretion of Proopiomelanocortin-Related Peptides in the Anterior Pituitary: A Study Using CRH-Deficient Mice, Neurosci. Lett., 2004, vol. 367, pp. 201–204.

    Article  PubMed  CAS  Google Scholar 

  3. Pugh, K., An Evaluation of the Corticotrophin-Releasing Hormone and Leptin Gene SNPs Relative to Cattle Behavior, M. Sc. Thesis, Univ. Saskatchewan, 2007.

  4. Davisa, E.P., Glynna, L.M., Schetterb, C.D., et al., Corticotropin-Releasing Hormone during Pregnancy is Associated with Infant Temperament, Dev. Neurosci., 2005, vol. 27, pp. 299–305.

    Article  Google Scholar 

  5. Vale, W., Spiess, J., River, C., et al., Characterization of a 41-Residue Ovine Hypothalmic Peptide That Stimulates Secretion of Corticotropin and Beta-Endorphin, Science 1981, vol. 213, pp. 1394–1397.

    Article  PubMed  CAS  Google Scholar 

  6. Lovejoy, D.A. and Balment, R.J., Evolution and Physiology of the Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Vertebrates, Gen. Comp. Endocrinol. 1999, vol. 115, pp. 1–22.

    Article  PubMed  CAS  Google Scholar 

  7. Wibowo, T.A., Michal, J.J., and Jiang, Z., The Corticotropin Releasing Hormone as a Strong Candidate Gene for Marbling and Subcutaneous Fat Depth in Beef Cattle, Genome, 2007, vol. 50, pp. 939–945.

    Article  PubMed  CAS  Google Scholar 

  8. King, B.R. and Nicholson, R.C., Advances in Understanding Corticotrophin-Releasing Hormone Gene Expression, Front. Biosci., 2007, vol. 12, pp. 581–590.

    Article  PubMed  CAS  Google Scholar 

  9. Statistica (Data Analysis Software System), Version 8.0., StatSoft Poland, 2008.

  10. Khatkar, M.S., Thomson, P.C., Tammen, I., et al., Quantitative Trait Loci Mapping in Dairy Cattle: Review and Meta-Analysis, Genet. Sel. Evol., 2004, vol. 36, pp.163–190

    Article  PubMed  CAS  Google Scholar 

  11. Cassar-Malek, I., Picard, B., Bernard, C., et al., Application of Gene Expression Studies in Livestock Production Systems: A European Perspective, Aust. J. Exp. Agric., 2008, vol. 48, pp. 701–710.

    Article  Google Scholar 

  12. Glantz, M., Lindmark Mansson, H., Stalhammar, H., et al., Effects of Animal Selection on Milk Composition and Processability, J. Anim. Sci., 2009, vol. 92, pp. 4589–4603.

    CAS  Google Scholar 

  13. Butson, S. and Berg, R.T., Factors Influencing Lactation Performance of Range Beef and Dairy Beef Cows, Can. J. Anim. Sci., 1984, vol. 64, pp. 267–277.

    Article  Google Scholar 

  14. Adriaens, F.A., Hard, D.L., Miller, M.A., et al., Pituitary Response to Thyrotropin, Corticotropin, and Gonadotropin-Releasing Hormones in Lactating Cows Treated with Sometribove for a Fourth Consecutive Lactation, Domest. Anim. Endocrinol., 1995, vol. 12, pp. 301–316.

    Article  PubMed  CAS  Google Scholar 

  15. Smaragdov, M.G., Prinzenberg, E.M., and Zwierzchowski, L., QTL Mapping in Cattle: Theoretical and Empirical Approach, Anim. Sci. Pap. Rep., 2006, vol. 24, pp. 69–110.

    Google Scholar 

  16. Sherman, E.L., Nkrumah, J.D., Murdoch, B.M., et al., Polymorphisms and Haplotypes in the Bovine Neuropeptide Y, Growth Hormone Receptor, Ghrelin, Insulin-Like Growth Factor 2, and Uncoupling Proteins 2 and 3 Genes and Their Associations with Measures of Growth, Performance, Feed Efficiency, and Carcass Merit in Beef Cattle, J. Anim. Sci., 2008, vol. 86, pp. 1–16.

    Article  PubMed  CAS  Google Scholar 

  17. Buchanan, F.C., Thue, T.D., Yu, P., et al., Single Nucleotide Polymorphisms in the Corticotrophin-Releasing Hormone and Proopiomelanocortin Genes Are Associated with Growth and Carcass Yield in Beef Cattle, Anim. Genet., 2005, vol. 36, pp. 127–131.

    Article  PubMed  CAS  Google Scholar 

  18. Panavi, G.S. and Lanchbury, J.S., Corticotropin Releasing Hormone Promoter Region Polymorphisms in Rheumatoid Arthritis, J. Rheumatol., 1997, vol. 24, pp. 215–216.

    Google Scholar 

  19. Murni, E., Muraniova, M., Ponsuksili, S., et al., Molecular Characterization and Evidencing of the Porcine CRH Gene as a Functional-Positional Candidate for Growth and Body Composition, Biochem. Biophis. Res. Commun., 2006, vol. 342, pp. 394–405.

    Article  Google Scholar 

  20. Murni, E., Ponsuksili, S., Schellander, K., et al., Association of Corticotropin-Releasing Hormone Gene Variation with Performance and Meat Quality Traits in Commercial Pig Lines, Anim. Genet., 2006, vol. 37, pp. 509–512.

    Article  Google Scholar 

  21. Buchanan, F.C., Thue, T.D., Winkelman-Sim, D.C., et al., Two QTLs for Growth Map to Bovine Chromosome 14, in International Conference on Animal Genetics, 2000, pp. 22–26.

  22. Buchanan, F.C., Thue, T.D., Elsasser, E.D., et al., A Corticotrophin-Releasing Hormone Polymorphism Associated with Post-Natal Growth in Beef Cattle, in Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, 2002, communication no. 11–32.

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Authors and Affiliations

  1. Department of Genetics and Animal Breeding, West Pomeranian University of Technology, Szczecin, 71466, Poland

    I. Kowalewska-Luczak, B. Wachelko & H. Kulig

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  1. I. Kowalewska-Luczak
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  2. B. Wachelko
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  3. H. Kulig
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Correspondence to I. Kowalewska-Luczak.

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Kowalewska-Luczak, I., Wachelko, B. & Kulig, H. The study of the SNP in the corticotropin-releasing hormone gene (Exon 2) and milk production traits in cattle. Russ J Genet 48, 543–547 (2012). https://doi.org/10.1134/S1022795412020093

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  • DOI: https://doi.org/10.1134/S1022795412020093

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