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CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (−76G > T), and CYP2S1 (13106C > T and 13255A > G) polymorphisms and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors

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Abstract

The contribution of the polymorphic markers of cytochrome P450 genes to respiratory diseases caused by smoking and occupational factors has been assessed. For this purpose, PCR-RFLP analysis of the CYP1B1 (rs1056836, 4326C > G), CYP2F1 (rs11399890, c.14_15insC), CYP2J2 (rs890293, -76G > T), and CYP2S1 (rs34971233, 13106C > T and rs338583, 13255A > G) gene polymorphisms has been performed. The analysis has shown that CYP1B1 (rs1056836, 4326C > G) and CYP2F1 (rs11399890, c.14_15insC) polymorphisms may contribute to the development of occupational chronic bronchitis. The proportion of CYP1B1*1*3 heterozygotes in the group of patients with occupational chronic bronchitis is considerably greater than in the group of healthy workers (69.16% versus 53.29%; χ2 = 5.94, p = 0.02, p cur = 0.04, OR = 1.97, the 95% CI is 1.13–3.42). Patients with occupational chronic bronchitis and healthy workers significantly differed from each other in the CYP2F1 genotypes frequency distribution (rs11399890, c.14_15insC) (χ2 = 6.18, d.f. = 2, p = 0.05). CYP2F1 wild type/ins heterozygous genotype frequency is higher in healthy workers (36.08%) than in patients (22.22%) (χ2 = 5.48, p = 0.02, p cur = 0.04, OR = 0.51, the 95% CI is 0.28–0.90). No association has been found between the CYP2J2 (rs890293, −76G > T) or CYP2S1 (rs34971233, 13106C > T, and rs338583, 13255A > G) gene polymorphisms and respiratory diseases.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Center, Ufa, 450054, Russia

    L. Z. Akhmadishina, G. F. Korytina & T. V. Victorova

  2. Bashkortostan State Medical University, Ufa, 450000, Russia

    T. V. Victorova

Authors
  1. L. Z. Akhmadishina
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  2. G. F. Korytina
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  3. T. V. Victorova
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Correspondence to L. Z. Akhmadishina.

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Original Russian Text © L.Z. Akhmadishina, G.F. Korytina, T.V. Victorova, 2011, published in Genetika, 2011, Vol. 47, No.10, pp. 1402–1410.

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Akhmadishina, L.Z., Korytina, G.F. & Victorova, T.V. CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (−76G > T), and CYP2S1 (13106C > T and 13255A > G) polymorphisms and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors. Russ J Genet 47, 1248–1255 (2011). https://doi.org/10.1134/S102279541109002X

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  • DOI: https://doi.org/10.1134/S102279541109002X

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