Skip to main content
SpringerLink
Log in

Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test

  • General Genetics
  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

The genotoxic and antigenotoxic effects of Cotinus coggygria Scop. methanol extract was investigated using the Drosophila sex-linked recessive lethal (or SLRL) test. The results presented here show that the methanol extract of Cotinus coggygria in a concentration of 5% and artificial chemical agent ethyl methanesulfonate EMS (0.75 ppm) induce recessive lethal mutations on X-chromosome on Drosophila melanogaster in all broods (I, II and III). Post-treatment with lower concentration of the methanol extract of Cotinus coggygria (2%) was effective in reducing genotoxicity of mutagen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Compositions and Methods of Inducing Hair Growth Utilizing Cotinus coggygria, Patent Application Publication US 2010/0221364 A1.

  2. Demirci, B., Demirci, F., and Baser, K.H., Composition of the Essential Oil of Cotinus coggygria (Scop.) from Turkey, Flavour. Fragr. J., 2003, vol. 18, pp. 43–44.

    Article  CAS  Google Scholar 

  3. Ivanova, D., Gerova, D., Chervenkov, T., and Yankova, T., Polyphenols and Antioxidant Capacity of Bulgarian Medicinal Plants, J. Ethnopharmacol., 2005, vol. 96, pp. 145–150.

    Article  PubMed  CAS  Google Scholar 

  4. Ingestible Compositions Containing Extract, Patent No. US 7,754,248 B2.

  5. Grieve, M.A., Modern Herbal, New York: Dover, 1971.

    Google Scholar 

  6. Cunha, K.S., Campesato, V.R., Reguly, M.L., et al., Tannic Acid is not Mutagenic in Germ Cells but Weakly Genotoxic in Somatic Cells of Drosophila melanogaster, Mutagenesis, 1995, vol. 10, no. 4, pp. 291–295.

    Article  PubMed  CAS  Google Scholar 

  7. Stathopoulou, K., Magitis, P., Karapanigiotis, I., et al., Phytochemical Analysis of Cotinus coggygria Heartwood: Identification of Isolated Colorants in Historical Art Objects, (Proc. of the 55th Int. Congres and Annu. Meeting of the Soc. for Med. Plant Res., Austria), Planta Med., 2007, vol. 73, p. 163.

    Article  Google Scholar 

  8. Valianou, L., Stathopoulou, K., Karapanagiotis, I., et al., Phytochemical Analysis of Young Fustic (Cotinus coggygria Heartwood) and Identification of Isolated Colourants in Historical Textiles, Anal. Bioanal. Chem., 2009, vol. 394, no. 3, pp. 871–872.

    Article  PubMed  CAS  Google Scholar 

  9. Puupponen-Pimia, R., Nohynek, L., Meier, C., et al., Antimicrobial Properties of Phenolic Compounds from Berries, J. Appl. Microbiol., 2001, vol. 90, no. 4, pp. 494–507.

    Article  PubMed  CAS  Google Scholar 

  10. Novaković, M., Vuković, I., Janacković, P., et al., Chemical Composition, Antibacterial and Antifungal Activity of the Essential Oils of Cotinus coggygria from Serbia, J. Serb. Chem. Soc., 2007, vol. 72, no. 11, pp. 1045–1051.

    Article  Google Scholar 

  11. Westenburg, H.E., Lee, K.J., Lee, S.K., et al., Activity-Guided Isolation of Antioxidative Constituents of Cotinus coggygria, J. Nat. Prod., 2000, vol. 63, no. 12, pp. 1696–1698.

    Article  PubMed  CAS  Google Scholar 

  12. Borchardt, J.R., Wyse, D.L., Sheaffer, C.C., et al., Antimicrobial Activity of Native and Naturalized Plants of Minnesota and Wisconsin, J. Med. Plants Res., 2008, vol. 2, no. 5, pp. 98–110.

    Google Scholar 

  13. Kilbey, B.J., Legator, M., Nichols, W., and Ramel, C., Handbook of Mutagenicity Test Procedures, Amsterdam: Elsevier, 1984.

    Google Scholar 

  14. Lee, W.R., Abrahamson, S., Valencie, R., et al., The Sex-Linked Recessive Lethal Test for Mutagenesis in Drosophila melanogaster: A Report of the US Environmental Protection Agency Gene-Tox Program, Mutat. Res., 1983, vol. 123, pp. 183–279.

    PubMed  CAS  Google Scholar 

  15. Lewis, E.B. and Bacher, F., Method of Feeding Ethyl Methane Sulfonate (EMS) to Drosophila Males, Drosophila Inform. Serv., 1968, vol. 43, p. 193.

    Google Scholar 

  16. Petz, B., Basic Statistical Method for Non-Mathematical Use, Zagreb: SNL, 1985.

    Google Scholar 

  17. Dauer, A., Hensel, A., Lhoste, E., et al., Genotoxic and Antigenotoxic Effects of Catechin and Tannins from the Bark of Hamamelis virginiana L. in Metabolically Component, Human Hepatoma Cells (Hep G2) Using Single Cell Gel Electrophoresis, Phytochemistry, 2003, vol. 63, pp. 199–207.

    Article  PubMed  CAS  Google Scholar 

  18. Stanić, S., Matić, S., Solujić, S., and Miloević, T., Genotoxicity Testing of the Methanol Extract of the Plant Cotinus coggygria and Gallic Acid on Drosophila melanogaster, Arch. Biol. Sci., 2009, vol. 61, no. 2, pp. 261–266.

    Article  Google Scholar 

  19. Birosová, L., Mikulasová, M., and Vaverková, S., Antimutagenic Effect of Phenolic Acids, Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Chech. Repub., 2005, vol. 149, no. 2, pp. 489–491.

    Google Scholar 

  20. Hajjouji, H.E., Pinelli, E., Guiresse, M., et al., Assement of the Genotoxicity of Olive Mill Waste Water (OMWW) with the Vicia faba Micronucleus Test, Mutat. Res.-Gen. Toxical. Environ Mutagen., 2007, vol. 634, nos. 1–2, pp. 25–31.

    Article  Google Scholar 

  21. Loveless, A., Increased Rate of Plaque-Type and Host-Range Mutation Following Treatment of Bacteriophage in vitro with Ethyl Methanesulphonate, Nature, 1958, vol. 181, pp. 1212–1213.

    Article  PubMed  CAS  Google Scholar 

  22. Schwartz, N.M., Nature of Ethyl Methanesulphonate Induced Reversions of Lac-Mutants of Escherichia coli, Genetics, 1963, vol. 48, pp. 1357–1375.

    PubMed  CAS  Google Scholar 

  23. Roebbelen, G., Wirkungsvergleich zwischen Thylmethansulfonat und Roentgenstrahlen im Mutationsversuch mit Arabidopsis thaliana, Naturwissenschaften, 1962, vol. 49, no. 3, p. 65.

    Article  Google Scholar 

  24. Ghatnekar, M.R., Primary Effects of Different Mutagens and the Disturbances Induced in the Meiosis of X and X2 of Vicia faba, Caryologia, 1964, vol. 17, pp. 219–244.

    Google Scholar 

  25. Drablos, F., Feyzi, E., Aas, P.M., et al., Alkylation Damage in DNA and RNA-Repair Mechanisms and Medical Significance, DNA Rep., 2004, vol. 3, pp. 1389–1407.

    Article  CAS  Google Scholar 

  26. Veld, C.W.O., Zdzienicka, M.Z., Vrieling, H., et al., Molecular Analysis of Ethyl Methanesulfonate-Induced Mutations at the hprt Gene in the Ethyl Methanesulfonate-Sensitive Chinese Hamster Cell Line EM-Cl and Its Parental Line CHO9, Cancer Res., 1994, vol. 54, pp. 3001–3006.

    Google Scholar 

  27. Fedeli, D., Berrettini, M., Gabryelak, T., and Falcioni, G., The Effect of Some Tannins on Trout Erythrocytes Exposed to Oxidative Stress, Mutat. Res., 2004, vol. 563, pp. 89–96.

    PubMed  CAS  Google Scholar 

  28. Graf, U., Abraham, S.K., Guzman-Rincon, J., and Wuergler, F.E., Antigenotoxicity Studies in Drosophila melanogaster, Mutat. Res., 1998, vol. 402, pp. 203–209.

    PubMed  CAS  Google Scholar 

  29. Ishaq, G.M., Shah, M.Y., and Tanki, S.A., Cancer Chemoprevention through Natural Antimutagenic Agents, JK-Practitioner: Internat. J. Cur. Med. Sci. and Practice, 2003, vol. 10, no. 2, pp. 101–106.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, 34000, Serbia

    S. Stanić, S. Matić & G. Đelić

  2. Department of Molecular Biology, Institute for Biological Research, University of Belgrade, Belgrade, Serbia

    M. Mihailović & D. Bogojević

  3. Department of Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, Serbia

    S. Solujić

Authors
  1. S. Stanić
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Matić
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Đelić
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Mihailović
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Bogojević
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Solujić
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Stanić.

Additional information

The article is published in the original.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stanić, S., Matić, S., Đelić, G. et al. Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test. Russ J Genet 47, 770–774 (2011). https://doi.org/10.1134/S1022795411070167

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1022795411070167

Keywords

Search

Navigation