Abstract
The present paper reports the distribution of serum protein markers viz. haptoglobin and transferrin in two major groups of Aligarh city of North India. In present study we have undertaken a survey of 538 individuals belonging to eight different populations, four from the Hindu community i.e. Brahmin, Bania, Rajput and Jatav, and the rest four among the Muslim community i.e. Syed, Sheikh, Pathan and Ansari. The heterozygosity ranged from 0.2939 (Ansari) to 0.4873 (Brahmin) for haptoglobin and from 0.000 (Rajput) to 0.1498 (Pathan) for transferrin. The values of D ST are 0.4122 and 0.4406, and that of G ST are 0.5059 and 0.9726 for haptoglobin and transferrin markers respectively. Through F ST test, it has been concluded that there is a high genetic differentiation of populations within Hindu and Muslim groups, though there is absence of any significant differences between these groups.
References
Malhotra, K.C., Morphological Composition of the People of India, J. Hum. Evol., 1978, vol. 7, no. 1, pp. 45–53.
Mukherjee, B.N., Majumder, P.P., Malhotra, K.C., et al., Genetic Polymorphism Analysis among Nine Endogamous Population Groups of Maharashtra, India, J. Hum. Evol., 1979, vol. 8, no. 6, pp. 555–565.
Karve, I., Hindu Society-an Interpretation, Poona: Deccan College, 1961.
Basu, A., Mukherjee, B.N., Roy, S., et al., Ethnic India: A Genomic View, with Special Reference to Peopling and Structure, Genome Res., 2003, vol. 13, pp. 2277–2290.
Majumder, P.P., Ethnic Populations of India as Seen from an Evolutionary Perspective, J. Biosci., 2001, vol. 26, no. 4, pp.533–545.
Majumder, P.P., Indian Caste Origins: Genomic Insights and Future Outlook, Genome Res., 2001, vol. 11, pp. 931–932.
Ansari, G., Muslim Caste in UP, Lucknow: Ethnographic and Folk Culture Soc., 1959.
Aarzoo, S.S. and Afzal, M., Gene Diversity in Some Muslim Populations of North India, Hum. Biol., 2007, vol. 77, pp. 343–353.
Ara, G., Sidique, Y.H., Beg, T., and Afzal, M., Gene Diversity among Some Muslim Populations of Western Uttar Pradesh, India, Anthropologist, 2008, vol. 10, no. 1, pp. 5–9.
Das, M.K., Das, K., and Mastana, S.S., Genetic Variation of Serum Proteins among the Koch Subpopulations of West Bengal, India, Int. J. Hum. Genet., 2002, vol. 2, no. 4, pp. 255–260.
Langlois, M.R., Martin, M.E., Boelaert, J.R., et al., The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males, Clin. Chem., 2000, vol. 46, no. 10, pp. 1619–1625.
Goud, J.D. and Rao, P.R., Transferrin, Haptoglobin and Group Specific Component Types in Tribal Populations of Andhra Pradesh, Hum. Hered., 1980, vol. 30, no. 1, pp. 7–12.
Langlois, M.R. and Delanghe, J.R., Biological and Clinical Significance of Haptoglobin Polymorphism in Humans, Clin. Chem., 1996, vol. 42, pp. 1589–1600.
Saraswathy, K.N. and Sachdeva, M.P., G6PD Deficiency, Sickle Cell Trait, Haptoglobin and Transferring Polymorphisms among Koyadoras and Nayakpods of Andhra Pradesh, Anthropologist 2008, vol. 10, no. 2, pp. 163–165.
Afzal, M., Ara, G., Sidique, Y.H., and Beg, T., Gene Diversity and Biochemical Markers among Some Muslim Populations of Uttar Pradesh, Anthrop. Anz., 2009, vol. 67, pp. 29–36.
Roychoudhury, S., Roy, S., Dey, B., et al., Fundamental Genomic Unity of Ethnic India is Revealed by Analysis of Mitochondrial DNA, Curr. Sci., 2000, vol. 79, no. 9, pp. 1182–1191.
Ashton, G.C. and Braden, A.W.H., Serum B Globin Polymorphism in Mice, Austr. J. Biol. Sci., 1961, vol. 14, pp. 248–253.
Nei, M., Analysis of Gene Diversity in Subdivided Populations, Proc. Nat. Acad. Sci. USA, 1973, vol. 70, pp. 3321–3323.
Nei, M. Genetic Distance between Populations, Amer. Nat., 1972, vol. 106, pp. 283–292.
Felsenstein, J., Phylip (Phylogeny Package) Version 3.5c, Seattle: Distributed by the Author, 1993.
Hutton, J.H., Caste in India, London: Oxford Univ. Press, 1961.
Eaaswarkanth, M., Dubey, B., Meganathan, P.R., et al., Diverse Genetic Origin of Indian Muslims: Evidence from Autosomal STR Loci, J. Hum. Genet., 2009, vol. 54, pp. 340–348.
Wirth, T., Wang, X., Linz, B., et al., Distinguishing Human Ethnic Groups by Means of Sequences from Helicobacter pylori: Lessons from Ladakh, Proc. Nat. Acad. Sci. USA, 2004, vol.101, no. 14, pp. 4746–4751.
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Ara, G., Siddique, Y.H. & Afzal, M. Gene diversity for haptoglobin and transferrin classical markers among Hindu and Muslim populations of Aligarh city, India. Russ J Genet 47, 744–748 (2011). https://doi.org/10.1134/S1022795411060044
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DOI: https://doi.org/10.1134/S1022795411060044