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Polymorphic markers of some genes associated with multiple sclerosis in the population of Kazakhstan

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Abstract

Associations of DR2 specificity of the DRB1 gene and single-nucleotide polymorphisms of the tumor necrosis factor gene TNFα (−308 G/A), interleukin genes IL-1β (−511 C/T), IL-2 (−475 A/T and −631 G/A), IL-6 (−634 C/G), paraoxanase gene PON1 (M55L, Q192R), and the mitochondrial protein transport gene UCP2 (−866 G/A) with the development of multiple sclerosis (MS) were studied in two main ethnic groups of Kazakhstan (Kazakhs and Russians). An association of DR2 specificity of the DRB1 gene with MS was found in the combined group of Kazakhs, Russians, and offsprings from mixed marriages. No correlation between DR2 specificity and MS was found in the separately examined groups of Kazakhs and Russians. Statistically significant (p < 0.05) differences between the MS patients and healthy individuals were observed in the distribution of the genotypes at site −634 G/C of the IL-6 gene in the Kazakh group, in the allelic frequencies at site −308 A/G in the promoter region of the TNFα gene in the Russian group, and in the frequencies of alleles at the polymorphic Q192R locus of the PON1 gene in the Kazakh group.. No significant differences were revealed in the distribution of the genotypes and in the frequencies of alleles at the polymorphic sites of the genes IL-1β (−511 C/T), IL-2 (−475 A/T and −631 G/A), PON1 (M55L), and UCP2 (−866 G/A).

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References

  1. Oksenberg, J.R., Baranzini, S.E., Barcellos, L.F., et al., Multiple Sclerosis: Genomic Rewards, J. Neuroimmunol., 2001, vol. 113, pp. 171–184.

    Article  PubMed  CAS  Google Scholar 

  2. Sawcer, S., Ban, M., Maranian, M., et al., A High-Density Screen for Linkage in Multiple Sclerosis: International Multiple Sclerosis Genetic Consortium, Am. J. Hum. Genet., 2005, vol. 77, pp. 454–467.

    Article  PubMed  Google Scholar 

  3. Hafler, D.A., Compston, A., Sawcer, S., et al., Risk Alleles for Multiple Sclerosis Identified by a Genome-wide Study, N. Engl. J. Med., 2007, p. 682.

  4. Wu, X., Zhao, H., and Shete, S., et al., P53 Genotypes and Haplotypes Associated with Lung Cancer Susceptibility and Ethnicity, J. Natl. Cancer Inst., 2002, vol. 94, pp. 681–690.

    PubMed  CAS  Google Scholar 

  5. Korytina, G.F., Akhmadishina, L.Z., Kochetova, O.V., et al., Association of Polymorphisms of the CYP1A1 and CYP1A2 Cytochrome P450 Genes with Chronic Obstructive Pulmonary Disease in Bashkortostan, Mol. Biol. (Moscow), 2008, no. 42, pp. 27–36.

  6. Sudomoina, M.A. and Favorova, O.O., A Search for Susceptibility Genes in Multiple Sclerosis, Mol. Biol. (Moscow), 2000, vol. 34, no. 4, pp. 654–670.

    Article  CAS  Google Scholar 

  7. Epplen, C., Jackel, S., Santos, E.J.M., et al., Genetic Predisposition to Multiple Sclerosis as Revealed by Immunoprinting, Ann. Neurol., 1997, vol. 4, no. 3, pp. 341–352.

    Article  Google Scholar 

  8. Hofman, F.M., Hinton, D.R., Johnson, K., et al., Tumor Necrosis Factor Identified in Multiple Sclerosis Brain, J. Exp. Med., 1989, vol. 170, no. 2, pp. 607–612.

    Article  PubMed  CAS  Google Scholar 

  9. You-Peng, C., Pfab, T., Slovinski, T., et al., Impact of Genetic Variation of Tumor Necrosis Factor-α on Hypertension, Chin. Med. J., 2006, vol. 119, no. 9, pp. 719–724.

    Google Scholar 

  10. Akira, S., Taga, T., and Kishimoto, T., Interleukin-6 in Biology and Medicine, Adv. Immunol., 1993, vol. 54, pp. 1–78.

    Article  PubMed  CAS  Google Scholar 

  11. Sainz, J., Perez, E., Gomez-Lopera, S., et al., Genetic Variants of IL6 Gene Promoter Influence on C-Reactive Protein Levels but Are not Associated with Susceptibility to Invasive Pulmonary Aspergillosis in Haematological Patients, Cytokine, 2008, vol. 41, no. 3, pp. 268–278.

    Article  PubMed  CAS  Google Scholar 

  12. Sidoti, A., Antognelli, C., Rinaldi, C., et al., Glyoxalase I A111E, Paraoxonase 1 Q192R and L55M Polymorphisms: Susceptibility Factors of Multiple Sclerosis?, Mult. Scler., 2007, vol. 13, pp. 446–453.

    PubMed  CAS  Google Scholar 

  13. Vogler, S., Goedde, R., Miterski, B., et al., Association of a Common Polymorphism in the Promoter of UCP2 with Susceptibility to Multiple Sclerosis, J. Mol. Med., 2006, vol. 83, pp. 1023–1028.

    Google Scholar 

  14. Matsuoka, T., Matsushita, T., Osoegawa, M., et al., Association of the HLA-DRB1 Alleles with Characteristic MRI Features of Asian Multiple Sclerosis, Mult. Scler., 2008, vol. 14, no. 9, pp. 1181–1190.

    Article  PubMed  CAS  Google Scholar 

  15. Wu, X.M., Wang, C., Zhang, K.N., et al., Association of Susceptibility to Multiple Sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 Alleles and DRB1-DPB1 Haplotypes: Distinct from Other Populations, Mult. Scler., 2009, vol. 15, no. 12, pp. 1422–1430.

    Article  PubMed  Google Scholar 

  16. Qiu, W., Wu, J.S., Castley, A., et al., Clinical Profile and HLA-DRB1 Genotype of Late Onset Multiple Sclerosis in Western Australia, J. Clin. Neurosci., 2010, vol. 23, no. 8, pp. 1009–1013.

    Article  Google Scholar 

  17. Wingo, T.S., Rosen, A., Cutler, D.J., et al., Paraoxonase-1 Polymorphisms in Alzheimer’s Disease, Parkinson’s Disease, and AD-PD Spectrum Diseases, Neurobiol. Aging, 2010, Oct 12, PM ID: 21311216.

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Authors and Affiliations

  1. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, 050012, Kazakhstan

    N. A. Aitkhozhina, V. G. Nigmatova, A. K. Khanseitova, M. A. Mendesh, E. E. Ashirbekov & T. S. Balmukhanov

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  1. N. A. Aitkhozhina
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  2. V. G. Nigmatova
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  3. A. K. Khanseitova
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  4. M. A. Mendesh
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  5. E. E. Ashirbekov
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  6. T. S. Balmukhanov
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Correspondence to N. A. Aitkhozhina.

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Original Russian Text © N.A. Aitkhozhina, V.G. Nigmatova, A.K. Khanseitova, M.A. Mendesh, E.E. Ashirbekov, T.S. Balmukhanov, 2011, published in Genetika, 2011, Vol. 47, No. 6, pp. 847–852.

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Aitkhozhina, N.A., Nigmatova, V.G., Khanseitova, A.K. et al. Polymorphic markers of some genes associated with multiple sclerosis in the population of Kazakhstan. Russ J Genet 47, 749–753 (2011). https://doi.org/10.1134/S1022795411060020

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  • DOI: https://doi.org/10.1134/S1022795411060020

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