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Genetic bases of the repertoire of immunoglobulins in application to diagnostics of clonality of B-cell lymphoid populations

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Abstract

Molecular mechanisms underlying the formation of B-cell lymphomas in connection with processes associated with the maturation of B-lymphocytes are reviewed. The currently used diagnostic methods do not always distinguish lymphomas from reactive changes of the lymphoid tissue. The principle of the molecular genetic method of clonality detection in lymphocyte populations, technical problems, and the strategy of its application in clinical diagnostics of lymphomas are described in detail.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    E. S. Zakharova & N. A. Kazilo

  2. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115578, Russia

    D. N. Stefanov, M. N. Sinitsyna & A. M. Kovrigina

Authors
  1. E. S. Zakharova
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  2. N. A. Kazilo
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  3. D. N. Stefanov
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  4. M. N. Sinitsyna
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  5. A. M. Kovrigina
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Correspondence to E. S. Zakharova.

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Original Russian Text © E.S. Zakharova, N.A. Kazilo, D.N. Stefanov, M.N. Sinitsyna, A.M. Kovrigina, 2011, published in Genetika, 2011, Vol. 47, No. 6, pp. 752–764.

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Zakharova, E.S., Kazilo, N.A., Stefanov, D.N. et al. Genetic bases of the repertoire of immunoglobulins in application to diagnostics of clonality of B-cell lymphoid populations. Russ J Genet 47, 662–673 (2011). https://doi.org/10.1134/S1022795411050188

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  • DOI: https://doi.org/10.1134/S1022795411050188

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