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Organ specificity of the genotoxic effects of cyclophosphane and dioxidine: An alkaline comet assay study

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Abstract

The applicability of alkaline comet assay to studying the organ specificity of the genotoxic effects of drugs has been estimated using cells from four organs of mice (the liver, lungs, spleen, and brain). It has been found that cyclophosphamide damages DNA in all the four organs; and dioxidine, in all organs except the brain. It is concluded that this method can be used for studying the organ specificity of the DNA-damaging effects of various substances.

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    K. G. Ordzhonikidze, A. M. Zanadvorova & S. K. Abilev

  2. Moscow State University, Moscow, 119001, Russia

    S. K. Abilev

Authors
  1. K. G. Ordzhonikidze
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  2. A. M. Zanadvorova
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  3. S. K. Abilev
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Correspondence to K. G. Ordzhonikidze.

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Original Russian Text © K.G. Ordzhonikidze, A.M. Zanadvorova, S.K. Abilev, 2011, published in Genetika, 2011, Vol. 47, No. 6, pp. 853–855.

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Ordzhonikidze, K.G., Zanadvorova, A.M. & Abilev, S.K. Organ specificity of the genotoxic effects of cyclophosphane and dioxidine: An alkaline comet assay study. Russ J Genet 47, 754–756 (2011). https://doi.org/10.1134/S1022795411050127

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  • DOI: https://doi.org/10.1134/S1022795411050127

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