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Y chromosome—a tool in infertility studies of Latvian population

Russian Journal of Genetics volume 47, pages 347–353 (2011)Cite this article

Abstract

Human Y chromosome is used as a tool in male infertility and population genetic studies. The aims of this research were to analyse the prevalence of Y chromosome microdeletions among infertile Latvian men, and to identify possible lineages of Y chromosome that may be at increased risk of developing infertility. A study encompassed 105 infertile men with different spermatogenic disturbances. Deletions on Y chromosome were detected in 5 out of 105 (∼5%) cases analysed in this study. Three of them carried deletion in AZFc region and two individuals had AZFa+b+c deletion. Study of Y chromosome haplogroups showed that N3a1 and R1a1 lineages were found less frequently in the infertile male group compared to ethnic Latvian group, however K* cluster was predominantly found in infertile male Y chromosomes. Conclusions: (1) Our study advocates running Y chromosome microdeletion analyses only in cases of severe form of infertility; (2) Ychromosome haplogroup analysis showed statistically significant tendencies that some haplogroups are more common in ethnic male group, but others are more common in infertile males.

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Authors and Affiliations

  1. Department of Medical Biology and Genetics, Riga Stradins University, Riga, LV-1007, Latvia

    A. Puzuka & A. Krumina

  2. Medical Genetics Clinic, Children University Hospital, Riga, Latvia

    N. Pronina, I. Grinfelde & Ja. Bars

  3. Laboratory of Andrology, Riga Stradins University, Riga, Latvia

    Ju. Erenpreiss

  4. EGV Clinics, Riga, Latvia

    V. Lejing

  5. Latvian Biomedical Research and Study Centre, Riga, Latvia

    L. Pliss, I. Pelnena & V. Baumanis

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  1. A. Puzuka
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  2. N. Pronina
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  3. I. Grinfelde
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  4. Ju. Erenpreiss
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  5. V. Lejing
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  6. Ja. Bars
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  7. L. Pliss
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  8. I. Pelnena
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  9. V. Baumanis
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  10. A. Krumina
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Correspondence to A. Puzuka.

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Puzuka, A., Pronina, N., Grinfelde, I. et al. Y chromosome—a tool in infertility studies of Latvian population. Russ J Genet 47, 347–353 (2011). https://doi.org/10.1134/S1022795411020141

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  • DOI: https://doi.org/10.1134/S1022795411020141

Keywords

  • Multiplex Polymerase Chain Reaction
  • Infertile Male
  • Azoospermia
  • Binary Marker
  • AZFc Deletion