Abstract
This study is a part of long-term investigations devoted to the analysis of the gene pool of Dagestan ethnic groups. The phenotype (in %), gene, and haplotype frequencies in Kumyk ethnic group are reported. A total of 39 alleles and six haplotypes of 14 loci (AB0, Rhesus, P, Levis, Kell, HP, GC, C’3, TF, 6PGD, GLO1, ESD, ACP, and PGM1) of immunobiochemical genetic marker systems were examined. Rare haplotypes of the Rhesus system were identified, including CDE in the Karabudakhkent population with the frequency of 0.030, and Cde and cdE in the Dorgeli population with the frequencies of 0.034 and 0.38, respectively. Similarly to the other ethnic populations of Dagestan examined, Kukyk populations carried rare, albeit typically “Caucasoid” gene ACP1 c of the AcP1 locus. The frequency of this allele in the two populations was similar, constituting 0.031 for Karabudakhkent and 0.032 for Dorgeli. In Kumyks, allele frequencies of the AB0, Rhesus, P, Lewis, Kell, HP, GC, C′3, TF, 6PGD, GLO1, ESD, ACP, but not PGM1, systems were similar to the mean allele frequencies at these loci observed in the other ethnic groups from the Dagestan, Caucasus, and the whole European historical ethnographic province. At the same time, the allele frequency values obtained were different from those for the populations of Kazakhstan, Central Asia, Siberia, and the Ruswsian Far East. Thus, the results obtained for classical genetic markers indicate that Kumyks are genetically closer to the indigenous populations of Dagestan than to Turkic-speaking populations. Analysis of the fit of the observed phenotype frequencies to the Hardy-Weinberg expectations showed that compared to other indigenous populations of Dagestan examined, in Kumyks the genetic state of the population upon random allele association was close to equilibrium. Probably, this state was determined by practical absence of the consanguineous marriages upon preservation of intra-aul endogamy.
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Marr, N.Ya., Plemennoi sostav naseleniya Kavkaza (Tribal Composition of the Caucasus Population), Petrograd, 1920.
Marr, N.Ya., Kavkazskie plemennye nazvaniya i mestnye paralleli (Caucasian Tribal Denominations and Local Parallels), Petrograd, 1922.
Fedorov-Guseinov, G.S., et al., Rannie tyurki na Severnom Kavkaze (Early Turks in the Northern Caucasus), Moscow, 1978.
Fedorov-Guseinov, G.S., et al., Istoriya Dagestana: Kurs lektsii (History of Dagestan: Lection Course), Makhachkala, 1992.
Fedorov-Guseinov, G.S., Istoriya proiskhozhdeniya kumykov (History of Kumyks’ Origin), Makhachkala, 1996.
Fedorov-Guseinov, G.S., Istoriya Karabudakhkenta (History of Karabudakhkent), Makhachkala, 1997.
Fedorov-Guseinov, G.S., Istoricheskie Korni Edinstva Narodov Dagestana (Historical Roots of Unity of the Peoples of Dagestan), Makhachkala, 2000.
Fedorov-Guseinov, G.S., Kumyki iz roda dagestanskogo (Dagestan-Born Kumyks), Makhachkala, 2001.
Fedorov-Guseinov, G.S., Vse my iz roda dagestanskogo (We Are All Dagestan-Born), Makhachkala, 2005.
Gadzhiev, A.G., Proiskhozhdenie narodov Dagestana (po dannym antropologii) (Origin of the Peoples of Dagestan (Inferred from Anthropological Data)), 1965.
Gadzhiev, A.G., Antropologiya Malykh Populyatsii Dagestana (Anthropology of the Small Populations of Dagestan), Makhachkala: Dagestanskyi Filial Akad. Nauk SSSR, 1971, vol. 368.
Bulaeva, K.B., Pavlova, T.A., and Bulaev, O.A., Genetic Polymorphism in Three Indigenous Populations of Dagestan, Russ. J. Genet., 1997, vol. 33, no. 10, pp. 1395–1405.
Nasidze, I.S., Inasaridze, Z.P., Shengeliya, L.A., and Shneider, Yu.V., Genetics of the Caucasus Population: Distribution of Some Immunological and Biochemical Markers in Dagestan ASSR, Genetika (Moscow), 1991, vol. 27, no. 9, pp. 1467–1474.
Radzhabov, M.O., Mamaev, I.A., Shamov, I.A., et al., Gene Pool of Dagestan Population: Genetic Structure of Nine First-Rate Populations (Using AB0 and Rhesus Blood Group Loci), Russ. J. Genet., 2009, vol. 45, no. 2, pp. 263–270.
Radzhabov, M.O., Mamaev, I.A., Shamov, I.A., et al., Gene Pool of Dagestan Population: Interethnic and Intraethnic Differentiation of Eight Aboriginal Ethnic Groups (Analysis Based on AB0 and Rhesus Erythrocyte Antigen Group Data), Russ. J. Genet., 2009, vol. 45, no. 3, pp. 370–375.
Genofond i genogeografiya narodonaseleniya (Gene Pool and Genogeography of Population), vol. 1: Genofond naseleniya Rossii i sopredel’nykh stran (Gene Pool of Population of Russia and Contiguous Countries), Rychkov, Yu.G., Ed., St. Petersburg: Nauka, 2000.
Genofond i genogeografiya narodonaseleniya (Gene Pool and Gene Geography of Human Populations), vol. 2: Genogeograficheskii atlas naseleniya Rossii i sopredel’nykh stran (Gene Geographical Atlas of Russia and Adjacent Countries), Rychkov, Yu.G., Ed., St. Petersburg: Nauka, 2003.
Spitsyn, V.A., Kukhkhoizer, V., Makarov, S.V., et al., The Russian Gene Pool: Frequencies of Genetic Markers, Russ. J. Genet., 2001, vol. 37, no. 3, pp. 308–314.
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Original Russian Text © M.O. Radzhabov, I.A. Shamov, D.G. Gasaev, I.N. Shilnikova, Yu.V. Shneider, I.V. Goldenkova-Pavlova, 2011, published in Genetika, 2011, Vol. 47, No. 2, pp. 260–267.
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Radzhabov, M.O., Shamov, I.A., Gasaev, D.G. et al. The Dagestan gene pool: Polymorphism of immunogenetic and biochemical markers in Kumyks. Russ J Genet 47, 230–236 (2011). https://doi.org/10.1134/S102279541101011X
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DOI: https://doi.org/10.1134/S102279541101011X