Abstract
The modern concept of intercalary heterochromatin as polytene chromosome regions exhibiting a number of specific characteristics is formulated. DNA constituting these regions is replicated late in the S period; therefore, some strands of polytene chromosomes are underrepresented; i.e., they are underreplicated. Late-replicating regions account for about 7% of the genome; genes are located there in clusters of as many as 40. In general, the gene density in the clusters is substantially lower than in the main part of the genome. Late-replicating regions have an inactivating capacity: genes incorporated into these regions as parts of transposons are inactivated with a higher probability. These regions contain a specific protein SUUR affecting the rate of replication completion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Prokof’eva-Bel’govskaya, A.A. and Khvostova, V.V., Distribution of Breaks along the X Chromosome of Drosophila melanogaster, Dokl. Akad. Nauk SSSR, 1939, vol. 23, pp. 269–271.
Kaufmann, B.P., Distribution of Induced Breaks along the X-Chromosome of Drosorhila melanogaster, Proc. Natl. Acad. Sci. USA, 1939, vol. 25, no. 11, pp. 571–577.
Painter, T.S., A New Method for the Study of Chromosome Aberrations and the Plotting of Chromosome Maps in Drosorhila melanogaster, Genetics, 1934, vol. 19, no. 3, pp. 175–188.
Zhimulev, I.F., Belyaeva, E.S., Makunin, I.V., et al., Influence of the SuUR Gene on Intercalary Heterochromatin in Drosorhila melanogaster Polytene Chromosome, Chromosoma, 2003, vol. 111, pp. 377–398.
Belyaeva, E.S., Zhimulev, I.F., Volkova, E.I., et al., Su(UR)ES: A Gene Suppressing DNA Underreplication in Intercalary and Pericentric Heterochromatin of Drosorhila melanogaster Polytene Chromosomes, Proc. Natl. Acad. Sci. USA, 1998, vol. 95, no. 13, pp. 7532–7537.
Makunin, I.V., Volkova, E.I., Belyaeva, E.S., et al., The Drosophila Suppressor of Underreplication Protein Binds to Late-Replicating Regions of Polytene Chromosomes, Genetics, 2002, vol. 160, no. 3, pp. 1023–1034.
van Steensel, B., Delrow, J., and Henikoff, S., Chromatin Profiling Using Targeted DNA Adenine Methyltransferase, Nat. Genet., 2001, vol. 27, pp. 304–308.
Pindyurin, A.V., Moorman, C., de Wit, E., et al., SUUR Joins Separate Subsets of PcG, HP1 and B-Type Lamin Targets in Drosophila, J. Cell Sci., 2007, vol. 120, pp. 2344–2351.
Belyakin, S.N., Christophides, G.K., Alekseyenko, A.A., et al., Fly Array Consortium: Kafatos, F.C. and Zhimulev, I.F., Genomic Analysis of Drosophila Chromosome Underreplication Reveals a Link between Replication Control and Transcriptional Territories, Proc. Natl. Acad. Sci. USA, 2005, vol. 102, no. 23, pp. 8269–8274.
Babenko, V.H., Pokholkova, G.V., Kokoza, E.B., et al., Characteristics of Molecular-Genetic Organization of Intercalary Heterochromatin Band 10A1-2 in X Chromosome of Drosorhila melanogaster, Dokl. Akad. Nauk, 2009, vol. 424, no. 3, pp. 407–410.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © I.F. Zhimulev, E.S. Belyaeva, E.N. Andreeva, N.G. Andreenkova, V.N. Babenko, S.N. Belyakin, L.V. Boldyreva, I.V. Brusentsova, S.A. Demakov, O.V. Demakova, I.A. Zykov, E.B. Kokoza, T.D. Kolesnikova, D.A. Maksimov, I.V. Makunin, A.V. Pindyurin, V.F. Semeshin, V.A. Khoroshko, 2010, published in Genetika, 2010, Vol. 46, No. 10, pp. 1405–1408.
Rights and permissions
About this article
Cite this article
Zhimulev, I.F., Belyaeva, E.S., Andreeva, E.N. et al. Intercalary heterochromatin in the genome of Drosophila . Russ J Genet 46, 1240–1242 (2010). https://doi.org/10.1134/S1022795410100248
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1022795410100248