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Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific hybrid voles

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Abstract

Interaction of transcription factor CTCF with the minimal promoter of Xist gene was investigated in intraspecific hybrids of common voles. CTCF was shown to bind with the minimal promoter region in vivo. However, the EMSA experiments resulted in the absence of interaction between the CTCF factor and its potential binding site. Probably, G(-43)A substitution influences binding efficacy of another transcription factor such as activator protein 2, AP2.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    K. E. Orischenko, E. A. Elisaphenko & S. M. Zakian

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  1. K. E. Orischenko
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  2. E. A. Elisaphenko
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  3. S. M. Zakian
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Correspondence to S. M. Zakian.

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Original Russian Text © K.E. Orischenko, E.A. Elisaphenko, S.M. Zakian, 2010, published in Genetika, 2010, Vol. 46, No. 10, pp. 1397–1400.

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Orischenko, K.E., Elisaphenko, E.A. & Zakian, S.M. Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific hybrid voles. Russ J Genet 46, 1233–1235 (2010). https://doi.org/10.1134/S1022795410100224

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  • DOI: https://doi.org/10.1134/S1022795410100224

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