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Association between the tryptophan hydroxylase (TpH) gene polymorphic markers and endogenous psychoses

  • Human Genetics
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Abstract

Tryptophan hydroxylase is one of the key enzymes involved in serotonergic metabolism. In many studies, an association between the TpH gene and human mentality, as well as mental disorders was demonstrated. This study was designed to analyze the association between three TpH gene polymorphisms (A218C, T3792A, and (CT) n (CA) n (CT) n ) and endogenous psychoses. The patients included into investigation were represented by those with manic-depressive psychosis (93 individuals) and those with the schizophrenia spectrum disorders (307 individuals). An association between the A218C polymorphism with the disorders of the schizophrenia spectrum was demonstrated. These findings confirmed the data obtained earlier for other populations. In addition, an association between the (CT) n (CA) n (CT) n microsatellite repeats and bipolar disease was shown for the first time.

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Authors and Affiliations

  1. Center for Advanced Medical Technologies, Moscow, 107014, Russia

    R. V. Efimov & A. S. Mavlyudova

  2. Department of Animal Ecology and Morphology, Saratov State University, Saratov, 410012, Russia

    R. V. Efimov

  3. Sechenov Moscow Medical Academy, Moscow, 119991, Russia

    R. V. Efimov

  4. Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, 115552, Russia

    V. E. Golimbet

Authors
  1. R. V. Efimov
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  2. A. S. Mavlyudova
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  3. V. E. Golimbet
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Correspondence to R. V. Efimov.

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Original Russian Text © R.V. Efimov, A.S. Mavlyudova, V.E. Golimbet, 2009, published in Genetika, 2009, Vol. 45, No. 12, pp. 1668–1673.

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Efimov, R.V., Mavlyudova, A.S. & Golimbet, V.E. Association between the tryptophan hydroxylase (TpH) gene polymorphic markers and endogenous psychoses. Russ J Genet 45, 1475–1479 (2009). https://doi.org/10.1134/S1022795409120114

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  • DOI: https://doi.org/10.1134/S1022795409120114

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