Abstract
The effects of mutations affecting the coat color on the dopamine, noradrenaline, and serotonin contents of the hypothalamus and brainstem of the American mink have been studied. The sample comprised standard (+/+) and mutant minks, including the monorecessive pastel (b/b), silver-blue (p/p), and white hedlund (h/h) and the combination double recessive sapphire (a/a p/p) and pearl (k/k p/p) ones. The dopamine content of the brainstem of the monorecessive pastel (b/b) and silver-blue (p/p) minks has been found to be higher than in standard (+/+) minks. Conversely, the homozigosity for two coat color loci in double recessive pearl minks (k/k p/p) significantly decreases the noradrenaline and serotonin contents of the hypothalamus. In addition, monorecessive and double recessive minks differ from each other in the serotonin contents of the midbrain and medulla.
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Il’ina, E.D. and Kuznetsov, G.A., Osnovy genetiki i selektsii pushnykh zverei (Principles of Fur Animal Genetics and Breeding), Moscow: Kolos, 1983.
Nes, N., Einarsson, E., Lohi, O., Jarosz, S., and Sheelje, R., Beautiful Fur Animals and Their Colour Genetics, Glostrup: Scientifur, 1988.
Trapezov, O.V., Black Crystal: A Novel Coat Color Mutant in the American Mink, J. Hered., 1997, vol. 88, pp. 164–166.
Koldaeva, E.M., Genetika i selektsiya (kniga pervaya) (Genetics and Breeding: Book 1), Moscow: Izvestiya, 2004.
Popova, N.K., Voitenko, N.N., Kulikov, A.V., et al., The Pleiotropic Effect of One-Locus (p/p) and Two-Locus (a/a p/p) Mutations of Mink Coat Color Genes on Serotonin Metabolism in the Brain, Russ. J. Genet., 1994, vol. 30, no. 11, pp. 1513–1515.
Popova, N.K., Nikulina, E.M., Voitenko, N.N., et al., The One-Locus Silver-Blue Fur Color Mutation (p/p) in Minks Affects the Dopamine System of the Brain, Russ. J. Genet., 1996, vol. 32, no. 3, pp. 452–454.
Voitenko, N.N. and Trapezov, O.V., Effect of Four Coat Color Mutations (SR, S, SH, and h) on Brain Monoamine Oxidase in Mink, Russ. J. Genet., 2001, vol. 37, no. 4, pp. 519–522.
Trapezov, O.V., Trapezova, L.I., and Sergeev, E.G., Effect of Coat Color Gene on the Behavioral Polymorphism in the Ranch-Bred American Mink (Mustela vison Schreber, 1777) and Sable (Martes zibellina Linnaeus, 1758), Russ. J. Genet., 2007, vol. 37, no. 4, pp. 519–522.
Felten, D.L. and Sladek, J.R., Monoamine Distribution in Primate Brain: V. Monoaminergic Nuclei: Anatomy, Pathways and Local Organization, Brain Res. Bull., 1983, vol. 58, no. 2, pp. 171–284.
Smith, S.E., Whitaker, C.H., Davis, L.F., and Nobel, P.V., The Inheritance of Three Coat Color Mutations in Ranch-Raised Mink, J. Hered., 1941, vol. 32, pp. 173–176.
Shackelford, R.M. and Cole, L.J., Screw-Neck in the Pastel Color Phase of Ranch-Bred Mink, J. Hered., 1947, vol. 38, pp. 203–209.
Shackelford, R.M., The Nature of Coat Colour Difference in Mink and Foxes, Genetics, 1948, vol. 33, pp. 311–336.
Shackelford, R.M. and Moore, W.L., Genetics Basis of Some White Phenotypes in the Ranch Mink, J. Hered., 1954, vol. 45, pp. 173–176.
Schlumpf, M., Lichensteiger, W., Langemann, H., et al., A Fluorometric Microtechnique for Simultaneous Assay of 5-Hydroxytryptamine, Noradrenaline and Dopamine in Milligrams of Brain Tissue, Biochem. Pharmacol., 1974, vol. 23, no. 6, pp. 2337–2346.
Trut, L.N., The Problem of Destabilizing Selection in Development, in Sovremennye kontseptsii evolyutsionnoi genetiki (Modern Concepts of Evolutionary Genetics), Novosibirsk, 2000, pp. 7–21.
Klochkov, D.V., Alekhina, T.A., Trapezov, O.V., and Petrenko, O.I., Estrus Circle, Folliculogenesis, Catecholamines after Horionic Gonadotropin Stimulation in Mink Selected for Behavior, Zh. Evol. Biokhim. Fiziol., 2005, vol. 41, no. 3, pp. 266–271.
Szot, P., Weinshenker, D., and White, S.S., Norepinephrine-Deficient Mice Have Increased Susceptibility to Seizure-Induced Stimuli, J. Neurosci., 1999, vol. 19, no. 24, pp. 10985–10992.
Alekhina, T.A., Prokudina, O.I., and Ryazanova, M.A., Typological Patterns of Behavior in Rats Selected for Elevating and Reducing of Pathological Moving, Linkage with Monoamines of Brain, Pavlov J. Higher Nerv. Act., 2007, vol. 57, no. 3, pp. 336–343.
Keeler, C.E., Coat Color, Physique, and Temperament, J. Heredity, 1947, vol. 9, pp. 271–277.
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Original Russian Text © O.V. Trapezov, L.I. Trapezova, T.A. Alekhina, D.V. Klochkov, Yu.N. Ivanov, 2009, published in Genetika, 2009, Vol. 45, No. 12, pp. 1641–1645.
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Trapezov, O.V., Trapezova, L.I., Alekhina, T.A. et al. Effects of monorecessive and double recessive mutations affecting coat color on the monoamine content of the brain of the American mink (Mustela vison Schreber, 1777). Russ J Genet 45, 1450–1453 (2009). https://doi.org/10.1134/S1022795409120072
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DOI: https://doi.org/10.1134/S1022795409120072