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Modern genetic approaches to searching for targets for medicinal preparations

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Abstract

In spite of a vast number of drug preparations used in medicine, advances in treating most socially important human diseases remain modest. Historically, many drugs were developed without clear understanding of the mechanisms of their action and were intended only for correcting symptoms of the disease. Identification of molecular targets in pharmacological screening new pharmaceuticals plays a key role not only in defining the strategy of the treatment, but also in understanding the general development of the disease. Sequencing of the genomes of various organisms, human in particular, and the development of new modern techniques of research have created the prerequisites for targeted screening for genes that are potentially interesting for development of new drugs.

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Authors and Affiliations

  1. St. Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, 188300, Russia

    S. V. Sarantseva & A. L. Schwarzman

  2. Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, 197376, Russia

    A. L. Schwarzman

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  1. S. V. Sarantseva
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Original Russian Text © S.V. Sarantseva, A.L. Schwarzman, 2009, published in Genetika, 2009, Vol. 45, No. 7, pp. 869–880.

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Sarantseva, S.V., Schwarzman, A.L. Modern genetic approaches to searching for targets for medicinal preparations. Russ J Genet 45, 761–770 (2009). https://doi.org/10.1134/S1022795409070011

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