Abstract
Association of 13 single nucleotide polymorphisms (SNPs) of insulinase (IDE) gene with type 2 diabetes mellitus (T2D) in the Moscow population has been examined. Three polymorphic markers (rs7078413, rs7899603, and rs551266) associated with the risk of T2D development have been revealed. Allele and genotype frequency distribution for these three markers differed significantly only in the sample of females between T2D patients and control individuals, while only in case of rs7078413 SNP genotype frequencies varied significantly in the total population.
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Original Russian Text © P.A. Slominsky, O.V. Pivovarova, M.I. Shadrina, A.V. Artem’eva, F.G. Pfaipffer, N.N. Rudovich, S.E. Agadghanyan, V.S. Pronin, S.A. Limborska, 2009, published in Genetika, 2009, Vol. 45, No. 1, pp. 127–131.
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Slominsky, P.A., Pivovarova, O.V., Shadrina, M.I. et al. Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population. Russ J Genet 45, 113–117 (2009). https://doi.org/10.1134/S1022795409010165
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DOI: https://doi.org/10.1134/S1022795409010165