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Deleterious mutations in various Drosophila melanogaster strains carrying meiotic mutation c(3)G

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Abstract

In the absence of meiotic recombination, deleterious mutations, decreasing the viability, are accumulated and fixed in small Drosophila populations. Study of the viability of hybrid progenies of three laboratory Drosophila melanogaster strains carrying meiotic mutation c(3)G 17 has suggested that the deleterious mutations are negatively synergistic in their interaction. The deleterious mutations localized to the pericentromeric region of chromosome 3 are threefold more efficient as compared with the mutations located in distal regions. Substitution of a new chromosome for the balancer chromosome in a strain with meiotic mutation c(3)G 17 partially restores (by ∼20%) the viability of homozygotes c(3)G 17/c(3)G 17 over the first 20–30 generations. Further cultivation for 30 generations with the same balancer again decreases the viability to the initial level. An epigenetic nature of deleterious mutations is discussed.

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  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    V. L. Chubykin

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  1. V. L. Chubykin
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Correspondence to V. L. Chubykin.

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Original Russian Text © V.L. Chubykin, 2008, published in Genetika, 2008, Vol. 44, No. 9, pp. 1209–1215.

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Chubykin, V.L. Deleterious mutations in various Drosophila melanogaster strains carrying meiotic mutation c(3)G . Russ J Genet 44, 1054–1060 (2008). https://doi.org/10.1134/S102279540809007X

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  • DOI: https://doi.org/10.1134/S102279540809007X

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