Abstract
The cellular function of the gilgamesh mutation (89B9-12) of casein kinase gene in Drosophila spermatogenesis was studied. It was demonstrated that the sterility resulting from this mutation is connected with the abnormalities in spermatid individualization. A phylogenetic study of the protein sequences of casein kinases 1 from various organisms was conducted. The Gilgamesh protein was shown to be phylogenetically closer to the cytoplasmic casein kinase family, represented by the YCK3, YCK2, and YCK1 proteins of Saccharomyces cerevisiae and animal γ-casein kinases. It is known that these yeast casein kinases are involved in vesicular trafficking, which, in turn, is related in its genetic control to the cell membrane remodeling during spermatid individualization. Thus, the data of phylogenetic analysis fit well the results obtained by studying the mutation phenotype.
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References
Hummel, T., Attix, S., Gunning, D., and Zipursky, S.L., Temporal Control of Glial Cell Migration in the Drosophila Eye Requires gilgamesh, hedgehog, and Eye Specification Genes, Neuron, 2002, vol. 33, no. 2, pp. 193–203.
Schulz, C., Kiger, A.A., Tazuke, S.I., et al., A Misexpression Screen Reveals Effects of Bag-of-Marbles and TGF Beta Class Signaling on the Drosophila Male Germ-Line Stem Cell Lineage, Genetics, 2004, vol. 167, no. 2, pp. 707–723.
Phatnani, H.P., Jones, J.C., and Greenleaf, A.L., Expanding the Functional Repertoire of CTD Kinase I and RNA Polymerase II: Novel PhosphoCTD-Associating Proteins in the Yeast Proteome, Biochemistry, 2004, vol. 43, no. 50, pp. 15702–15719.
Fuller, M, Spermatogenesis, in The Development of Drosophila melanogaster, Bate, M. and Martinez Arias, A.P., Eds., New York: Cold Spring Harbor Lab., 1993, pp. 71–147.
Fabricio, J., Hime, G., Lemmon, S., and Bazinet, C., Genetic Dissection of Sperm Individualization in Drosophila melanogaster, Development, 1998, vol. 125, pp. 1833–1843.
Seto, E.S., Bellen, H.J., and Lloyd, T.E., When Cell Biology Meets Development: Endocytic Regulation of Signaling Pathways, Genes Dev., 2002, vol. 16, no. 11, pp. 1314–1336.
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Original Russian Text © O.O. Nerusheva, N.V. Dorogova, N.V. Gubanova, L.V. Omel’yanchuk, 2008, published in Genetika, 2008, Vol. 44, No. 9, pp. 1203–1208.
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Nerusheva, O.O., Dorogova, N.V., Gubanova, N.V. et al. The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis. Russ J Genet 44, 1049–1053 (2008). https://doi.org/10.1134/S1022795408090068
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DOI: https://doi.org/10.1134/S1022795408090068