Skip to main content
SpringerLink
Log in

Gene polymorphism of the renin-angiotensin system in six ethnogeographic regions of Belarus

  • Human Genetics
  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

The insertion/deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and the T174M polymorphism of the angiotensinogen gene (AGT) have been studied in six ethnogeographic regions of Belarus. Significant intrapopulation differences in ACE genotype frequencies have been found for the northern and eastern regions (the Dvina and Dnepr basins, respectively). Significant differences in the AGT genotype frequencies have been found between populations of the Dnepr basin and populations of all other Belarusian regions. The allele and genotype frequencies of the genes studied in the Belarusian population and populations of other regions of the world have been compared. The frequencies of the insertion (I) and deletion (D) alleles of the ACE gene in the Belarusian population are 50.7 and 49.3%, respectively, which is similar to these frequencies in European countries. The frequency of the M allele of the AGT gene in Belarus is 16.6%, which is higher than its frequency in populations of European, African, and Asian origins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Grody, W.W., Molecular Genetic Risk Screening, Annu. Rev. Med., 2003, vol. 54, pp. 473–490.

    Article  PubMed  CAS  Google Scholar 

  2. Genomika—meditsine: Nauchnoe izdanie (Genomics for Medicine: A Scientific Publication), Ivanov, V.I. and Kiseleva, L.L, Eds., Moscow: Akademkniga, 2005.

    Google Scholar 

  3. Mustafina, O.E., Nasibbulin, T.R., and Khusnutdinova, E.K., Association of the T174M Polymorphism of the Angiotensinogen Gene with Essential Hypertension in Russians and Tatars from Bashkortostan, Mol. Biol. (Moscow), 2002, vol. 36, no. 4, pp. 648–653.

    Google Scholar 

  4. Chistyakov, D.A., Turakulov, R.I., Moiseev, V.S., and Nosikov, V.V., Polymorphism of the Angiotensinogen II T174M Gene and Cardiovascular Diseases in the Moscow Population, Russ. J. Genet., 1999, vol. 35, no. 8, pp. 999–1002.

    CAS  Google Scholar 

  5. Yamagishi, K., Iso, H., Tanigawa, T., et al., High Sodium Intake Strengthens the Association between Angiotensinogen T174M Polymorphism and Blood Pressure Levels among Lean Men and Women: A Community-Based Study, Hypertens. Res., 2004, vol. 27, no. 1, pp. 53–60.

    Article  PubMed  CAS  Google Scholar 

  6. Agachan, B., Isbir, T., Yilmaz, H., and Akoglu, E., Angiotensin Converting Enzyme I/D, Angiotensinogen T174M-M235T and Angiotensin II Type 1 Receptor A1166C Gene Polymorphism in Turkish Hypertensive Patients, Exp. Mol. Med., 2003, vol. 35, no. 6, pp. 545–549.

    PubMed  CAS  Google Scholar 

  7. Limborska, S.A., Khusnutdinova, E.K., and Balanovskaya, E.V., Etnogenomika i genogeografiya narodov Vostochnoi Evropy (Ethnogenomics and Gene Geography of the East European Populations), Moscow: Nauka, 2002.

    Google Scholar 

  8. Cidl, K., Strelcova, L., Vasku, A., et al., Angiotensin I-Converting Enzyme (ACE): A Review of I/D Polymorphism in the World Populations, Scr. Med., (Brno), 1997, vol. 70, nos. 2/3, pp. 81–87.

    Google Scholar 

  9. Fernandez-Arcas, N., Dieguez-Lucena, J., Munoz-Moran, E., et al., Both Alleles of the M235T Polymorphism of the Angiotensinogen Gene Can Be a Risk Factor for Myocardial Infarction, Clin. Genet., 2001, vol. 60, pp. 52–57.

    Article  PubMed  CAS  Google Scholar 

  10. Mendonca, I., Freitas, I.A., Sousa, C.A., et al., Angiotensin Converting Enzyme Gene Polymorphisms and Coronary Risk in a Portuguese Population, Rev. Port. Cardiol., 2004, vol. 23, no. 12, pp. 1593–1601.

    PubMed  Google Scholar 

  11. Czarnecka, D., Kawecka-Jaszcz, K., Stolarz, K., et al., Genetic Factors in Hypertension. Angiotensin-Converting Enzyme Polymorphism, Kardiol. Pol., 2004, vol. 61, no. 7, pp. 1–10.

    PubMed  Google Scholar 

  12. Mondry, A., Loh, M., Liu, P., et al., Polymorphisms of the Insertion/Deletion ACE and M235T AGT Genes and Hypertension: Surprising New Findings and Meta-Analysis of Data, BMC Nephrol., 2005, vol. 6, no. 1.

  13. Saeed, M., Saleheen, D., Siddiqui, S., et al., Association of Angiotensin Converting Enzyme Gene Polymorphisms with Left Ventricular Hypertrophy, Hypertens. Res., 2005, vol. 28, pp. 345–349.

    Article  PubMed  CAS  Google Scholar 

  14. Al-Eisa, A., Haider, M., and Srivastva, B., Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphisms in Idiopathic Nephrotic Syndrome in Kuwaiti Arab Children, Scand. J. Urol. Nephrol., 2001, vol. 35, pp. 239–242.

    Article  PubMed  CAS  Google Scholar 

  15. Mathew, C.C., The Isolation of High Molecular Weight DNA, Meth. Mol. Biol., 1984, vol. 2, pp. 31–34.

    CAS  Google Scholar 

  16. Prasad, N., O’Kane, K., Johnstone, H., et al., The Relationship between Blood Pressure and Left Ventricular Mass in Essential Hypertension Is Observed only in the Presence of the Angiotensin-Converting Enzyme Gene Deletion Allele, Quart. J. Med., 1994, vol. 87, pp. 659–662.

    CAS  Google Scholar 

  17. Sabbagh, A., Otrock, Z., Mahfoud, Z., et al., Angiotensin-Converting Enzyme Gene Polymorphism in the Lebanese Population: Prevalence and Review of the Literature, Mol. Biol. Rep., 2007, vol. 34, pp. 47–52.

    Article  PubMed  CAS  Google Scholar 

  18. Kushnerevich, E.I., Sivitskaya, L.N., Danilenko, N.G., et al., Mitochondrial DNA Diversity in Modern Belarusians, Dokl. Nats. Akad. Navuk Belarusi, 2007, no. 1, pp. 79–83.

  19. Kushniarevich, A.I., Sivitskaya, L.N., Danilenko, N.G., et al., Y-Chromosome Gene Pool of Belarusians: Clues from Biallelic Markers Study, Dokl. Nats. Akad. Navuk Belarusi, 2007, vol. 51, no. 5, pp. 100–105.

    CAS  Google Scholar 

  20. Verbenko, A.D., Knjazev, A.N., Mikulich, A.I., et al., Variability of the 3’ApoB Minisatellite Locus in Eastern Slavonic Populations, Hum. Hered., 2005, vol. 60, pp. 10–18.

    Article  PubMed  CAS  Google Scholar 

  21. Glotov, O.S., Glotov, A.S., Tarasenko, O.A., et al., Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphisms in Elderly Subjects, Athletes, and Patients with Coronary Heart Disease, in Genetika v XXI veke: sovremennoe sostoyanie i perspektivy razvitiya (Genetics in the 21st Century: State of the Art and Prospects), Moscow: Vseross. O-vo Genet. Selekts., 2004, vol. 2, p. 62.

    Google Scholar 

  22. Svyatova, G.S., Berezina, G.M., Abdullaeva, A.M., et al., Nuclear Genes ACE and eNOS3 Polymorphism Analysis in a Kazakh Population, in Genetika v KhKhI veke: sovremennoe sostoyanie i perspektivy razvitiya (Genetics in the 21st Century: State of the Art and Prospects), Moscow: Vseross. O-vo Genet. Selekts., 2004, vol. 2, p. 158.

    Google Scholar 

  23. Vasku, V., Vasku, J., Goldbergova, M., et al., Association of Variants in Angiotensin-Converting Enzyme and Endothelin-1-Genes with Phototherapy in Cutaneous T-Cell Lymphoma, Acta Dermatoven APA, 2004, vol. 13, no. 4, pp. 111–117.

    CAS  Google Scholar 

  24. Tiret, L., Mallet, C., Poirier, O., et al., Lack of Association between Polymorphisms of Eight Candidate Genes and Idiopathic Dilated Cardiomyopathy: The CARDI-GENE Study, J. Am. Coll. Cardiol., 2002, vol. 35, pp. 29–35.

    Article  Google Scholar 

  25. Schiavello, E., Burke, V., and Bogdanova, N., Angiotensin-Converting Enzyme Activity and the ACE Alu Polymorphism in Autosomal Dominant Polycystic Kidney Disease, Nephrol. Dial. Transplant., 2001, vol. 16, pp. 2323–2327.

    Article  PubMed  CAS  Google Scholar 

  26. Vassilikioti, S., Doumas, M., Douma, S., et al., Angiotensin Converting Enzyme Gene Polymorphism Is Not Related to Essential Hypertension in a Greek Population, Am. J. Hypertens., 1996, vol. 9, no. 7, pp. 700–702.

    Article  PubMed  CAS  Google Scholar 

  27. Mattu, R., Needham, E., Galton, D., et al., A DNA Variant at the Angiotensin-Converting Enzyme Gene Locus Associates with Coronary Artery Disease in the Caerphilly Heart Study, Circulation, 1995, vol. 91, pp. 270–274.

    PubMed  CAS  Google Scholar 

  28. Barley, J., Blackwood, A., Cartel, N., et al., Angiotensin Converting Enzyme Insertion/Deletion Polymorphism: Association with Ethnic Origin, J. Hypertens., 1994, vol. 12, pp. 955–957.

    Article  PubMed  CAS  Google Scholar 

  29. Merlo, J., Bengtsson-Bostrom, K., Lindblad, U., et al., Multilevel Analysis of Systolic Blood Pressure and ACE Gene I/D Polymorphism in 438 Swedish Families: A Public Health Perspective, BMC Med. Genet., 2006, vol. 7, pp. 14–25.

    Article  PubMed  Google Scholar 

  30. Shaheenul, I., Lehtimaki, T., Juonala, M., et al., Polymorphism of the Angiotensin-Converting Enzyme (ACE) and Angiotesinogen (AGT) Genes and Their Associations with Blood Pressure and Carotid Artery Intima Media Thickness among Healthy Finnish Young Adults: The Cardiovascular Risk in Young Finns Study, Atherosclerosis, 2006, vol. 188, pp. 316–322.

    Article  Google Scholar 

  31. Morshed, M., Khan, H., and Akhteruzzaman, S., Association between Angiotensin I-Converting Enzyme Gene Polymorphism and Hypertension in Selected Individuals of the Bangladeshi Population, J. Biochem. Mol. Biol., 2002, vol. 35, no. 3, pp. 251–254.

    PubMed  CAS  Google Scholar 

  32. Pasha, M.A., Khan, A.P., Kumar, R., et al., Variations in Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Indian Populations of Different Ethnic Origins, J. Biosci., 2002, vol. 27, no. 1, pp. 67–70.

    Article  PubMed  CAS  Google Scholar 

  33. Uhm, W., Lee, H., Chung, Y., et al., Angiotensin-Converting Enzyme Gene Polymorphism and Vascular Manifestations in Korean Patients with SLE, Lupus, 2002, vol. 11, pp. 227–233.

    Article  PubMed  CAS  Google Scholar 

  34. Lee, E.J., Population Genetics of the Angiotensin-Converting Enzyme in Chinese, Brit. J. Clin. Pharmacol., 1994, vol. 37, pp. 212–214.

    CAS  Google Scholar 

  35. Tamaki, S., Nakamura, Y., Tsujita, Y., et al., Polymorphism of the Angiotensin Converting Enzyme Gene and Blood Pressure in a Japanese General Population (the Shigaraki Study), Hypertens. Res., 2002, vol. 25, no. 6, pp. 120–126.

    Article  Google Scholar 

  36. Duru, K., Farrow, S., Wang, J., et al., Frequency of a Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme Is Increased in African-Americans with Hypertension, Am. J. Hypertens., 1994, vol. 7, pp. 759–762.

    PubMed  CAS  Google Scholar 

  37. Nasibulin, T.R., Mustafina, O.E., Tuktarova, I.A., et al., Analysis of the Angiotensinogen Gene T174M Polymorphism in Populations of the Volga-Ural Region, Russ. J. Genet., 2004, vol. 40, no. 10, pp. 1163–1168.

    Article  Google Scholar 

  38. Gardman, A., Stricker, J., Hume, J., et al., Angiotensinogen T174M and M235T Gene Polymorphisms Are Associated with the Extend of Coronary Atherosclerosis, Atherosclerosis, 1999, vol. 145, pp. 309–314.

    Article  Google Scholar 

  39. Wang, J.H., Lin, C.M., Wang, L.S., et al., Association between Molecular Variants of the Angiotensinogen Gene and Hypertension in Amis Tribes of Eastern Taiwan, J. Formos. Med. Assoc., 2002, vol. 101, no. 3, pp. 183–188.

    PubMed  CAS  Google Scholar 

  40. Rotimi, C., Puras, A., Cooper, R., et al., Polymorphism of Renin-Angiotensin Genes Among Nigerians, Jamaicans and African Americans, Hypertension, 1996, vol. 27, pp. 558–563.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, 220072, Belarus

    L. N. Sivitskaya, E. I. Kushniarevich, N. G. Danilenko & O. G. Davydenko

  2. Department of Ethnology, Belarusian State University, Minsk, 220030, Belarus

    T. A. Novogrodski

Authors
  1. L. N. Sivitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. I. Kushniarevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. G. Danilenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. A. Novogrodski
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. G. Davydenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. N. Sivitskaya.

Additional information

Original Russian Text © L.N. Sivitskaya, E.I. Kushniarevich, N.G. Danilenko, T.A. Novogrodski, O.G. Davydenko, 2008, published in Genetika, 2008, Vol. 44, No. 5, pp. 702–709.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sivitskaya, L.N., Kushniarevich, E.I., Danilenko, N.G. et al. Gene polymorphism of the renin-angiotensin system in six ethnogeographic regions of Belarus. Russ J Genet 44, 609–616 (2008). https://doi.org/10.1134/S1022795408050141

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1022795408050141

Keywords

Search

Navigation