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Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin

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Abstract

The effect of mutation for gene Merlin on chromosome disjunction in Drosophila during meiosis was genetically studied. Chromosome nondisjunction was not registered in females heterozygous for this mutation and containing structurally normal X chromosomes. In cases when these females additionally contained inversion in one of chromosomes X, a tendency toward the appearance of nondisjunction events was observed in individuals containing mutation in the heterozygote. The genetic construct was obtained allowing the overexpression of protein corresponding to a sterile allele Mer 3 in the germ cell line. This construct relieves the lethal effect of Mer 4 mutation. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis.

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References

  1. Algrain, M., Arpin, M., and Louvard, D., Wizardry at the Cell Cortex, Curr. Biol., 1993, vol. 3, pp. 451–454.

    Article  CAS  PubMed  Google Scholar 

  2. McCartney, B.M. and Fehon, R.G., Distinct Cellular and Subcellular Patterns of Expression Imply Distinct Functions for the Drosophila Homologues of Moesin and the Neurofibromatosis 2 Tumor Suppressor, Merlin, J. Cell Biol., 1996, vol. 133, pp. 843–852.

    Article  CAS  PubMed  Google Scholar 

  3. LaJeunesse, D.R., McCartney, B.M., and Fehon, R.G., Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization, J. Cell Biol., 1998, vol. 141, pp. 1589–1599.

    Article  CAS  PubMed  Google Scholar 

  4. MacDougall N., Lad Y., Wilkie G. et al., Merlin, the Drosophila Homologue of Neurofibromatosis-2, is Specifically Required in Posterior Follicle Cells for Axis Formation in the Oocyte, Development, 2001, vol. 128, pp. 665–673.

    CAS  PubMed  Google Scholar 

  5. Ito, K., Awano, W., and Yamamoto, D., Cell Lineage Analysis of Adult Fly Brains Using the FLIPPASE/FRT and GAL4/UAS Systems, J. Neurogenet., 1997, vol. 11, pp. 164–165.

    Google Scholar 

  6. Shilova, I.E. and Omelyanchuk, L.V., A Method for Transformation of Drosophila Germline Cells with a High-Concentration Exogenous DNA, Russ. J. Genet., 2007, vol. 43, no. 1, pp. 80–83.

    Article  CAS  Google Scholar 

  7. Ashburner, M., Golic, K.G., and Hawley, R.S., Drosophila: A Laboratory Handbook, New York: Cold Spring Harbor Lab., 2005.

    Google Scholar 

  8. Chadov, B.F., From Phenomena of Nondisjunction to the Problem of Chromosome Coorientation (on the Occasion of the 75th Anniversary of Bridges’ Article Publication), Genetika (Moscow), 1991, vol. 27, no. 11, pp. 1877–1903.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Division, Novosibirsk, 630090, Russia

    O. S. Yudina, A. M. Gusachenko, E. M. Akhmamet’eva & L. V. Omelyanchuk

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  1. O. S. Yudina
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  2. A. M. Gusachenko
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  3. E. M. Akhmamet’eva
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  4. L. V. Omelyanchuk
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Correspondence to L. V. Omelyanchuk.

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Original Russian Text © O.S. Yudina, A.M. Gusachenko, E.M. Akhmamet’eva, L.V. Omelyanchuk, 2008, published in Genetika, 2008, Vol. 44, No. 3, pp. 414–416.

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Yudina, O.S., Gusachenko, A.M., Akhmamet’eva, E.M. et al. Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin. Russ J Genet 44, 357–359 (2008). https://doi.org/10.1134/S1022795408030186

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  • DOI: https://doi.org/10.1134/S1022795408030186

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