Skip to main content
SpringerLink
Log in

Cell estimates of genetic damage repair under the epigenetic effect of the rad201(G1) mutation in Drosophila

  • General Genetics
  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

Cell estimates of genetic damage repair were obtained to characterize the epigenetic effect of the rad201(G1) mutation. The estimates included morphological defects (malformations); the frequency of chromosome aberrations in somatic cells; and somatic mosaicism, reflecting double-strand break repair via conversion. The range and frequency of malformations significantly differed between the rad201(G1) epigenetic effect and irradiation. A high pupal lethality, detected upon P-element mobilization, was not associated with an increase in the frequency of cells with chromosome aberrations, while somatic mosaicism was far greater. The results are discussed in the context of differences between radiation and P-element mutagenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Khromykh, Yu.M., Varentsova, E.R., Sarantseva, S.V., and Kotlovanova, L.V., Epigenetic Effect of the rad201(G1) Mutation in a System with Mobilization of Nonautonomous P Elements in Drosophila, Genetika, 2008, vol. 44, no. 3, pp. 295–300.

    CAS  Google Scholar 

  2. Banga, S.S., Velazquez, A., and Boyd, J.B., P Transposition in Drosophila Provides a New Tool for Analyzing Postreplication Repair and Double-Strand Break Repair, Mutat. Res., 1991, vol. 255, pp. 79–88.

    CAS  PubMed  Google Scholar 

  3. Engels, W.R., Johnson-Shlitz, D.M., Eggleston, W.B., and Sved, J.A., High Frequency P Element Loss in Drosophila Is Homolog Dependent, Cell, 1990, vol. 62, pp. 515–525.

    Article  CAS  PubMed  Google Scholar 

  4. Henderson, D.S. and Glover, D., Chromosome Fragmentation Resulting from an Inability to Repair Transporase-Induced DNA Double-Strand Breaks in PCNA Mutants of Drosophila, Mutagenesis, 1998, vol. 13, pp. 57–60.

    Article  CAS  PubMed  Google Scholar 

  5. Flybase: Revision 3 2003, http://flybase.bio.indiana.edu

  6. Chubykin, V.L. and Omel’yanchuk, L.V., Apoptosis in Developing and Adult D. melanogaster, Ontogenez, 1999, vol. 30, pp. 417–428.

    CAS  PubMed  Google Scholar 

  7. Levina, V.V., Cytogenetic Study of Radiosensitivity of Various Drosophila Strains, Cand. Sci. (Biol.) Dissertation, St. Petersburg: Inst. Nucl. Phys., 1992.

    Google Scholar 

  8. Volchkov, Yu.A. and Aleksandrov, Yu.N., X-ray Dose Dependence of the Frequency of Radiation-Induced Malformations, Vestn. Leningr. Univ., 1972, vol. 1, pp. 95–105.

    Google Scholar 

  9. Lebedeva, L.I., Trunova, S.A., and Omel’yanchuk, L.V., Genetic Control of Mitosis: The Modified Adaptive Expression of the v158 Mutation, Russ. J. Genet., 2000, vol. 36, no. 10, pp. 1130–1135.

    CAS  Google Scholar 

  10. Rubin, G.M., Kidwell, M.G., and Bingham, P.M., The Molecular Basis of P-M Hybrid Dysgenesis: The Nature of Induced Mutations, Cell, 1982, vol. 29, pp. 987–994.

    Article  CAS  PubMed  Google Scholar 

  11. Engels, W.R., Benz, W.K., Preston, C.R., et al., Somatic Effects of P Element Activity in Drosophila melanogaster, Genetics, 1987, vol. 117, pp. 745–757.

    CAS  PubMed  Google Scholar 

  12. Togashi, S., Ueda, R., Takahisa, M., et al., Developmental Profile of P Element Transposition in Drosophila Somatic Cells, Genetics, 1993, vol. 88, pp. 147–152.

    CAS  Google Scholar 

  13. Khromykh, Yu.M. and Levina, V.V., Study of Radiosensitive Drosophila Lines: XII. Realization of Effects of the rad(2)201(G1) Mutation at the Cell and Organismic Levels, Genetika (Moscow), 1990, vol. 26, p. 1203–1210.

    Google Scholar 

  14. Fritz-Niggli, H., Radiobiologiya, ee osnovy i dostizheniya (Radiobiology: Fundamentals and Achievements), Moscow: Gosatomizdat, 1962.

    Google Scholar 

  15. Preston, C.R. and Engels, W.R., P-Element-Induced Male Recombination and Gene Conversion in Drosophila, Genetics, 1996, vol. 144, pp. 1611–1622.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Konstantinov St. Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188350, Russia

    L. V. Kotlovanova, E. R. Varentsova, S. V. Sarantseva & Yu. M. Khromykh

Authors
  1. L. V. Kotlovanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. R. Varentsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. V. Sarantseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu. M. Khromykh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. V. Sarantseva.

Additional information

Original Russian Text © L.V. Kotlovanova, E.R. Varentsova, S.V. Sarantseva, Yu.M. Khromykh, 2008, published in Genetika, 2008, Vol. 44, No. 3, pp. 353–358.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kotlovanova, L.V., Varentsova, E.R., Sarantseva, S.V. et al. Cell estimates of genetic damage repair under the epigenetic effect of the rad201(G1) mutation in Drosophila . Russ J Genet 44, 301–305 (2008). https://doi.org/10.1134/S1022795408030095

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1022795408030095

Keywords

Search

Navigation