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Functions of transcription factor TRF2 Drosophila melanogaster

  • Molecular Genetics
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Abstract

A study was made of the function of the Drosophila melanogaster TRF2 protein. Expression analysis of the trf2 P1 mutation implicated TRF2 in the D. melanogaster embryo development. High-level expression of the trf2 gene was observed in female germline cells. A high level of TRF2 was detected in primary spermatocytes and trophocytes, characterized by intense transcription. In the female gonads, TRF2 was detected in both nurse cells with intense transcription and transcriptionally inactive oocyte nuclei. In addition, TRF2 proved to be necessary for premeiotic chromatin condensation and further differentiation of germline cells.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    D. V. Kopytova, E. N. Nabirochkina, N. E. Vorobyova, S. G. Georgieva & A. N. Krasnov

  2. Center of Medical Research in Russia, University of Oslo, Moscow, 119334, Russia

    E. N. Nabirochkina, S. G. Georgieva & A. N. Krasnov

  3. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia

    M. R. Kopantseva & S. G. Georgieva

Authors
  1. D. V. Kopytova
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  2. M. R. Kopantseva
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  3. E. N. Nabirochkina
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  4. N. E. Vorobyova
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  5. S. G. Georgieva
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  6. A. N. Krasnov
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Corresponding author

Correspondence to D. V. Kopytova.

Additional information

Original Russian Text © D.V. Kopytova, M.R. Kopantseva, E.N. Nabirochkina, N.E. Vorobyova, S.G. Georgieva, A.N. Krasnov, 2008, published in Genetika, 2008, Vol. 44, No. 3, pp. 309–314.

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Kopytova, D.V., Kopantseva, M.R., Nabirochkina, E.N. et al. Functions of transcription factor TRF2 Drosophila melanogaster . Russ J Genet 44, 260–265 (2008). https://doi.org/10.1134/S1022795408030034

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  • DOI: https://doi.org/10.1134/S1022795408030034

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