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Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow

  • Human Genetics
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Abstract

To map human chromosome 2 region associated with type 1 diabetes mellitus, 89 families with concordant and discordant sib pairs were analyzed. Linkage and association with type 1 diabetes were examined using polymorphic microsatellite markers spanning the region of about 4 Mb. The linkage plot was constructed, and association of the five microsatellite markers within the chromosomal region 2q35 was examined. Polymorphic marker D2S137 (Z′ = 3.225, p c = 0.0048) demonstrated maximum linkage and association with type 1 diabetes.

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Authors and Affiliations

  1. State Research Institute of Genetic and Selection of Industrial Microorganisms, Moscow, 117545, Russia

    A. Chernisheva, N. M. Tsitlidze, K. V. Savost’anov & V. V. Nosikov

  2. Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow, 117036, Russia

    L. I. Zil’berman, T. L. Kuraeva, V. A. Peterkova & I. I. Dedov

Authors
  1. A. Chernisheva
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  2. N. M. Tsitlidze
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  3. K. V. Savost’anov
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  4. L. I. Zil’berman
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  5. T. L. Kuraeva
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  6. V. A. Peterkova
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  7. I. I. Dedov
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  8. V. V. Nosikov
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Corresponding author

Correspondence to V. V. Nosikov.

Additional information

Original Russian Text © A. Chernisheva, N.M. Tsitlidze, K.V. Savost’anov, L.I. Zil’berman, T.L. Kuraeva, V.A. Peterkova, I.I. Dedov, V.V. Nosikov, 2008, published in Genetika, 2008, Vol. 44, No. 2, pp. 232–235.

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Chernisheva, A., Tsitlidze, N.M., Savost’anov, K.V. et al. Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow. Russ J Genet 44, 193–196 (2008). https://doi.org/10.1134/S1022795408020117

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  • DOI: https://doi.org/10.1134/S1022795408020117

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