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Study of the Drosophila melanogaster trf2 gene and its protein product

  • Molecular Genetics
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Abstract

The Drosophila melanogaster TRF2 protein regulates transcription of several genes. The trf2 gene structure was studied. The gene proved to code for two protein isoforms, a known 75-kDa isoform and a newly identified 175-kDa isoform. The new isoform combines the known isoform sequence with an extended N end containing a coiled-coil motif. The long TRF2 isoform was found to act as a component of a multiprotein complex, including ISWI ATPase as well.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    D. V. Kopytova, Yu. V. Nikolenko, L. A. Lebedeva, E. N. Nabirochkina, Yu. V. Shidlovskii, S. G. Georgieva & A. N. Krasnov

  2. Center of Medical Research in Russia, University of Oslo, Moscow, 119334, Russia

    E. N. Nabirochkina, S. G. Georgieva & A. N. Krasnov

  3. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia

    S. G. Georgieva

Authors
  1. D. V. Kopytova
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  2. Yu. V. Nikolenko
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  3. L. A. Lebedeva
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  4. E. N. Nabirochkina
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  5. Yu. V. Shidlovskii
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  6. S. G. Georgieva
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  7. A. N. Krasnov
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Correspondence to D. V. Kopytova.

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Original Russian Text © D.V. Kopytova, Yu.V. Nikolenko, L.A. Lebedeva, E.N. Nabirochkina, Yu.V. Shidlovskii, S.G. Georgieva, A.N. Krasnov, 2008, published in Genetika, 2008, Vol. 44, No. 2, pp. 163–169.

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Kopytova, D.V., Nikolenko, Y.V., Lebedeva, L.A. et al. Study of the Drosophila melanogaster trf2 gene and its protein product. Russ J Genet 44, 131–136 (2008). https://doi.org/10.1134/S1022795408020026

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  • DOI: https://doi.org/10.1134/S1022795408020026

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