Abstract
The geographic distribution of hereditary diseases (HDs) in different populations and ethnic groups of Russia has been studied. The main patterns of the formation of the prevalence and spectrum of HDs in five ethnic groups (Russians from six regions, Mari, Chuvashes, Udmurts, and Adygeans) from a total of ten regions of Russia have been analyzed. Analysis of correlations suggests that genetic drift is the main factor of the genetic differentiation of populations with respect to the prevalence of HDs. Accumulation of HDs in individual populations and ethnic groups has been analyzed. Hereditary diseases characterized by locally high prevalence rates in individual populations or ethnic groups have been detected. The main patterns of the accumulation of individual diseases and differences between populations and ethnic groups in this respect have been studied with the use of principal component analysis, which describes these patterns more graphically. It has been demonstrated that the genes of HDs are a promising tool for characterizing ethnogenetic processes in populations.
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References
Nasledstvennye bolezni v populyatsiyakh cheloveka (Hereditary Diseases in Human Populations), Ginter, E.K, Ed., Moscow: Meditsina, 2002.
Mediko-geneticheskoe opisanie naseleniya Adygei (Medical Genetic Description of the Adygea Population), Ginter, E.K, Ed., Maikop, 1997.
Zinchenko, R.A., El’chinova, G.I., and Ginter, E.K., Genetic Epidemiology of Hereditary Diseases, in Sovremennye tekhnologii geneticheskikh issledovanii (Modern Technologies of Genetic Research), Chernyshev, V.N, Ed., Rostov-on-Don, 2004, pp. 16–24.
Zinchenko R.A., El’chinova G.I., Nurbaev S.D., and Ginter E.K., Diversity of Autosomal Dominant Disorders in the Populations of Russia, Russ. J. Genet., 2001, vol. 37, no. 3, pp. 290–301.
Zinchenko R.A., El’chinova G.I., Gavrilina, S.G., and Ginter E.K., Analysis of Diversity of Autosomal-Recessive Diseases in Russian Populations, Russ. J. Genet., 2001, vol. 37, no. 11, pp. 1293–1298.
Zinchenko, R.A., El’chinova, G.I., and Ginter, E.K., Ethnic Characteristics of Hereditary Diseases in the Populations of Russia, in Alekseevskie chteniya (Alexeev Conference), Moscow, 2004, pp. 254–255.
Nei, M, Mathematic Models of Speciation and Genetic Distance, in Population Genetic and Ecology, Karlin, S. and Nero, E., Eds., New York: Academic, 1976, pp. 723–765.
Zhivotovsky, L.A., Populyatsionnaya biometriya (Population Biometry), Moscow: Nauka, 1991, pp. 128–130.
Deryabin, V.E., Mnogomernaya biometriya dlya antropologov (Multivariate Biometry for Anthropologists), Moscow: Mosk. Gos. Univ., 1983.
Zinchenko, R.A., El’chinova, G.I., Balanovskaya, E.V., et al., The Influence of Population Genetic Structure on the Prevalence of Monogenetic Hereditary Diseases in Russian Populations, Vestn. Ross. Akad. Med. Nauk, 2000, no. 5, pp. 5–10.
Ginter, E.K. and Zinchenko, R.A., Hereditary Disorders in Russian Populations, Vestn. VOGiS, vol. 10, no. 1, pp. 106–125.
Zinchenko R.A., El’chinova G.I., and Ginter E.K., Association between Endogamy Index of Russian Populations, Occasional Inbreeding and Hereditary Disease Prevalence, Med. Genet., 2003, vol. 2, no. 9, pp. 432–436.
Ginter, E.K., Zinchenko, R.A., El’chinova, G.I., et al., The Role of Population Dynamics in the Hereditary Pathology Distribution in Russian Populations, Med. Genet., 2004, vol. 3, no. 12, pp. 548–555.
Zinchenko, R.A., El’chinova, G.I., Timkovskaya, E.E., et al., Differentiation of Ethnic Groups in Russia with Respect to the Genes of Hereditary Diseases: The Fifth Meeting of Medical Geneticists, Ufa, May 2005, Med. Genet., 2005, vol. 4, no. 4, p. 190.
Zinchenko, R.A., Mordovtseva, V.V., Petrov, A.N, and Ginter, E.K., Hereditary Recessive Hypotrichosis in Marii-El and Chuvashia, Med. Genet., 2003, vol. 2, no. 6, pp. 267–272.
Bliznets, E.A., Kirillov, A.G., Ginter, E.K., et al., Molecular Genetic Factors of Osteopetrosis in Chuvashia, Med. Genet., 2005, vol. 4, no. 7, pp. 315–321.
Vasserman, N.N., Tverskaya, S.M., Zinchenko, R.A., and Polyakov, A.V., Population Frequency of the C598T Mutation in the VHL Gene Leading to Autosomal Recessive Erythrocytosis: The Fifth Meeting of Medical Geneticists, Ufa, May 2005, Med. Genet., 2005, vol. 4, no. 4, p. 165.
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Original Russian Text © R.A. Zinchenko, G.I. El’chinova, N.V. Baryshnikova, A.V. Polyakov, E.K. Ginter, 2007, published in Genetika, 2007, Vol. 43, No. 9, pp. 1246–1254.
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Zinchenko, R.A., El’chinova, G.I., Baryshnikova, N.V. et al. Prevalences of hereditary diseases in different populations of Russia. Russ J Genet 43, 1038–1045 (2007). https://doi.org/10.1134/S1022795407090104
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DOI: https://doi.org/10.1134/S1022795407090104